Genome mapping by means of radiation-induced interspecific cell hybrids is a direct means for localizing both high- and low-polymorphic nucleotide sequences, including gene sequences, on animal chromosomes. Using radiation hybrid panels either individual chromosomes and loci or the entire genome can be mapped. This is a novel efficient approach that allows one to reach high resolution of markers (up to 100 bp) and unify the mapping language. Due to electronic means of communication, the same experimental material can be used in numerous laboratories to provide high-resolution extended genomic maps saturated with markers. Radiation hybrid mapping is a powerful tool for the analysis of the complex genome structure. Using radiation hybrid maps permitted to verify regions of chromosome homeology in various species and to detect regions not only with conserved sequences but also with conserved gene order. Identification of these regions is extremely important for understanding evolution of species karyotypes. It permits the use of positional cloning to isolate genes controlling commercially valuable traits and those involved in the development of hereditary human diseases.
Russian Journal of Genetics – Springer Journals
Published: Oct 13, 2004
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