Genetic variability of the small t antigen of the novel KI, WU and MC polyomaviruses

Genetic variability of the small t antigen of the novel KI, WU and MC polyomaviruses Recently, three novel human polyomaviruses were discovered: KIPyV, WUPyV and MCPyV. To study the genetic variability of these viruses, an evolutionary analysis of the large T antigen, small t antigen, VP1, VP2 and VP3 genes was carried out. Of the genes analyzed, only the small t antigen of KIPyV and MCPyV was found to be under statistically supported selective pressure. In KIPyV, 31 selected sites were found under positive selection (ω 2 = 1.54), with posterior probabilities above 0.75. Of these sites, 17 are located in the J domain and two of these are located in the HPDGG box. Thirteen of these sites were identified as being under positive selection at the 99% confidence level. Moreover, seven codons were under significant purifying selection, particularly in the J domain. In MCPyV, we confirmed the five sites already found to be under positive selection (posterior probabilities 0.99). Selective pressure analysis may provide useful information on viral evolution. Archives of Virology Springer Journals

Genetic variability of the small t antigen of the novel KI, WU and MC polyomaviruses

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Springer Vienna
Copyright © 2010 by Springer-Verlag
Biomedicine; Infectious Diseases; Medical Microbiology ; Virology
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