Curr Diab Rep (2017) 17: 129 https://doi.org/10.1007/s11892-017-0961-5 PATHOGENESIS OF TYPE 1 DIABETES (A PUGLIESE, SECTION EDITOR) 1 2 3 Maria J. Redondo & Richard A. Oram & Andrea K. Steck Published online: 28 October 2017 Springer Science+Business Media, LLC 2017 . . . . . Abstract Keywords Type 1 diabetes Genetic Risk Score HLA Purpose of Review About 50% of the heritability of type 1 Prediction diabetes (T1D) is attributed to human leukocyte antigen (HLA) alleles and the remainder to several (close to 50) non-HLA loci. A current challenge in the field of the genetics Introduction of T1D is to apply the knowledge accumulated in the last 40 years towards differential diagnosis and risk assessment. The incidence of type 1 diabetes (T1D) has dramatically Recent Findings T1D genetic risk scores seek to combine the increased in recent years (3–4%/year), with the most rapid information from HLA and non-HLA alleles to improve the increase seen in children younger than 5 years of age . accuracy of diagnosis, prediction, and prognosis. Here, we de- Besides the personal and family burden of the disease, the scribe genetic risk scores that have been developed and validat- economic cost of T1D at all ages
Current Diabetes Reports – Springer Journals
Published: Oct 28, 2017
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