Genetic Risk Scores for Type 1 Diabetes Prediction and Diagnosis

Genetic Risk Scores for Type 1 Diabetes Prediction and Diagnosis Curr Diab Rep (2017) 17: 129 PATHOGENESIS OF TYPE 1 DIABETES (A PUGLIESE, SECTION EDITOR) 1 2 3 Maria J. Redondo & Richard A. Oram & Andrea K. Steck Published online: 28 October 2017 Springer Science+Business Media, LLC 2017 . . . . . Abstract Keywords Type 1 diabetes Genetic Risk Score HLA Purpose of Review About 50% of the heritability of type 1 Prediction diabetes (T1D) is attributed to human leukocyte antigen (HLA) alleles and the remainder to several (close to 50) non-HLA loci. A current challenge in the field of the genetics Introduction of T1D is to apply the knowledge accumulated in the last 40 years towards differential diagnosis and risk assessment. The incidence of type 1 diabetes (T1D) has dramatically Recent Findings T1D genetic risk scores seek to combine the increased in recent years (3–4%/year), with the most rapid information from HLA and non-HLA alleles to improve the increase seen in children younger than 5 years of age [1]. accuracy of diagnosis, prediction, and prognosis. Here, we de- Besides the personal and family burden of the disease, the scribe genetic risk scores that have been developed and validat- economic cost of T1D at all ages Current Diabetes Reports Springer Journals

Genetic Risk Scores for Type 1 Diabetes Prediction and Diagnosis

Loading next page...
Springer US
Copyright © 2017 by Springer Science+Business Media, LLC
Medicine & Public Health; Diabetes
Publisher site
See Article on Publisher Site

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial