Mammalian Genome 10, 191–193 (1999). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1999 Genetic polymorphisms in the leptin gene and their association with fatness in four pig breeds Zhi-Hua Jiang, John P. Gibson Centre for Genetic Improvement of Livestock, Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, Canada N1G 2W1 Received: 3 September 1998 / Accepted: 8 October 1998 Fatness in pigs is of economic importance because of market in- Inner primers for the Bi-PASA genotyping of the C/T substi- centives for production of lean pork and because increasing fatness tution at 867 were: C allele specific, 58GGG GTG GGG TCT GGG increases the feed costs of production. Leptin, a 16-kDa protein GTC TCA GCG38, and T allele specific, 58GGG GTG GGG TGG secreted from white adipocytes, is involved in the regulation of AGG GGG CGT TT38. Inner primers for the polymorphism at food intake, energy expenditure, and whole-body energy balance 3714 were: G allele specific, 58GGG GCG GGG TGC AGC ATG in rodents and humans (Behme 1996; Frederich et al. 1995; House- TCC TGC38, and T allele specific, 58GGG GTG GCG GTG CAG knecht et al. 1998; and MacDougald et al. 1995). A mutation
Mammalian Genome – Springer Journals
Published: Feb 1, 1999
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