Current data on genetic determinants of virulence in Listeria monocytogenesand on factors affecting their expression are reviewed. The role of the PrfA protein, the only known transcriptional regulator that directly affects virulence gene expression and mechanisms responsible for the activity and/or concentration of this protein in the cell are considered. Detailed information of external signals modulating the level of virulence factor expression is provided. Data that favor the involvement of autoregulatory processes in the expression of virulence genes are considered, and a model of regulation to explain these data is proposed.
Russian Journal of Genetics – Springer Journals
Published: Oct 12, 2004
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