Hymmalian Short Communications Genome Incorp—ting Mouse Genome © Springer-Verlag New York Inc. 1998 Mammalian Genome 9, 240-242 (1998). Genetic mapping of the galanin-GMAP (Gain) gene to mouse Chromosome 19 Leticia C. Guida, l '* Philippa Charlton, 3°** Debra J. Gilbert,' Nancy A. Jenkins, Neal G. Copeland,' Robert D. Nicholls' 'Department of Genetics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio, 44106-4955, USA 2Center for Human Genetics, University Hospitals of Cleveland, 10900 Euclid Avenue, Cleveland, Ohio, 44106-4955, USA 'Division of Endocrinology, Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina 27599, USA 4Mammalian Genetics Laboratory, ABL-Basic Research Program, NCI-Frederick Cancer Research and Developmental Center, Frederick, Maryland 21702, USA Received: 5 September 1997 /Accepted: 18 November 1997 The galanin-GMAP gene (Gain) encodes preprogalanin, which is enzymatically cleaved into the peptides galanin and galanin mes- sage-associated peptide (GMAP; Fig. la; Rokaeus 1994). Galanin mRNA and peptide have been detected widely in the central and peripheral nervous systems, in endocrine tissues such as the hy- pothalamus, anterior pituitary, pancreas, adrenal, thyroid and para- thyroid glands, and in developing bone (Rokaeus 1994; Xu et al. 1996). Physiological studies suggest that galanin modulates neu- roendocrine systems by affecting satiety, the development of
Mammalian Genome – Springer Journals
Published: Mar 21, 2009
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