Genetic mapping of the Brca2 breast cancer susceptibility gene on mouse Chromosome 5

Genetic mapping of the Brca2 breast cancer susceptibility gene on mouse Chromosome 5 540 Mammalian Genome 8, Brief Data Reports Segregation of RFLVs in an interspecific mouse backcross Database deposit information: Genebank Accession Number: panel allowed the assignment of two loci. One locus occurs on Chr U89503 11 in a region with previously established homology to human Chr Molecular reagents used for mapping: A 1.3-kb hybridization 17, consistent with the location of human profilin 1 (PFN1; see probe containing exon 10 of the human BRCA2 gene [2,3] was generated by PCR (5'-TTTCTATGAGAAAGGTTGTGAG and Fig. 1). Our mapping data thus place the Pfnl gene near previously mapped mutations including oe (open eyelid), co (cocked), and 5'-AGCAGAAAAAAACACAGAAGGA). This probe was used Mdsh (Miller-Dieker syndrome homolog). Interestingly, in some to identify a Bacterial Artificial Chromosome clone, (593D1), by humans with Miller-Dieker syndrome, the PFN1 gene is deleted, hybridization screening of high density filters containing the CJ7 but in others it appears intact [5]. Thus, allelic deletion of the embryonic stem cell line library (Research Genetics, Huntsville, AL) derived from a 129Sv mouse. Subsequently, a 407-bp EcoRV profilin locus may contribute to the clinical phenotype of Miller- Dieker syndrome in some patients, but does not determine the fragment from the BAC 593D1 bacterial artificial chromosome essential Mammalian Genome Springer Journals

Genetic mapping of the Brca2 breast cancer susceptibility gene on mouse Chromosome 5

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Copyright © 1997 by Springer-Verlag
Life Sciences; Cell Biology; Anatomy; Zoology
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