Mammalian Genome 9, 256-258 (1998). Mymmafian Genome Incorporating Mouee Genome © Springer-Verlag New York Inc. 1998 Genetic mapping of Afr2 (Rif): regulator of gene expression in liver regeneration David K. Jin, Miriam H. Feuerman Department of Biochemistry, Box 8, State University of New York, Health Science Center at Brooklyn, 450 Clarkson Avenue, Brooklyn, New York 11203, USA Received: 21 October 1997 / Accepted: 17 November 1997 Alpha-fetoprotein (AFP) is a classic oncofetal antigen. The AFP lation should have the paternal C3H/HeJ-specific sequence, serv- gene is highly expressed during gestation in the visceral endoderm ing as a positive control for the assay. SSLP markers genetically of yolk sac, fetal liver, and the gastrointestinal tract (Andrews et al. linked to Afr2 would yield a higher frequency of the C57BL/6J 1982; Tilghman and Belayew 1982), but is repressed to an almost sequence relative to the C3H/HeJ sequence in the low AFP- undetectable level in the adult liver (Tilghman and Belayew 1982). expressing population. The D2Mit2O8 locus was closely linked to Expression of the AFP gene can be re-activated in response to liver Afr2 as all the high AFP-expressing mice were Afr2^a homozy- regeneration induced by partial hepatectomy or acute carbon tet- gotes,
Mammalian Genome – Springer Journals
Published: Mar 21, 2009
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