Mammalian Genome 12, 80–82 (2001). DOI: 10.1007/s003350010233 Incorporating Mouse Genome © Springer-Verlag New York Inc. 2001 Genetic mapping of a neurological mutation cerebellar calcification in the rat 1,2 1 1 1 1 2 Yosuke Ando, Shigehito Takeshita, Kazunori Fujimoto, Miyuki Shimizu, Mayumi Nagata, Tateki Kikuchi, Noboru Wakasugi Medicinal Safety Research Laboratories, Sankyo Co., Ltd., Fukuroi, Shizuoka 437-0065, Japan Department of Animal Models for Human Disease, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, 187-8502, Japan Laboratory of Animal Reproduction, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa-ku, Nagoya, 464-8601, Japan Received: 14 June 2000 / Accepted: 31 August 2000 The rat genetic map has been markedly improved with application female rats were used for production of both F and backcross of PCR-analyzed microsatellite markers, particularly gene-derived generations, since reproduction of the homozygous (cc/cc)CC and anonymous SSLP markers, in combination with cytogenetical males was very low. WKY was an inbred strain established from th methods for clarification of coverage, orientation, and centromere a stock of Wistar rats and used for the present study at the 37–38 position (Rat Genome Database 1999; Rat Genome Data 1999). generations of brother-sister matings. All animals were maintained With this progress, comparative mapping studies between the
Mammalian Genome – Springer Journals
Published: Jan 1, 2001
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