Mammalian Genome 9, 324-326 (1998). Mammalian Genome Mouse Cenone Incorporating © Springer-Verlag New York Inc. 1998 Genetic isolation of iddm I on Chromosome 4 in the BioBreeding (BB) rat Sabine Bieg,' G. Koike, 2 J. Jiang,' L. Klaff, l A. Pettersson, 3 A.J. MacMurray,4 H.J. Jacob,2 E.S. Lander, 4 A. Lernmark' 'Robert H. Williams Laboratory, Department of Medicine, Box 357710, University of Washington, Seattle, Washington 98195, USA 2Department of Physiology, Wisconsin Medical College, Milwaukee, Wisconsin, USA 'Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA 'Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA Received: 12 September 1997 / Accepted: 22 December 1997 Iddm 1 in the BioBreeding (BB) rat designates the genomic region remained at approximately 25%, confirming the Mendelian mode on rat Chromosome (Chr) 4 that harbors the gene causing periph- of inheritance for iddm 1 in both female and male F2 rats (Table 1). eral T cell lymphopenia (Lyp) and diabetes (Jacob et al. 1992). We By the 3rd cycle, 100% of both female and male Lyp/Lyp rats here report the generation of a novel congenic Lyp/Lyp Dr rat line, would develop diabetes. Except in the 5th cycle, during which the in which iddm 1 has been
Mammalian Genome – Springer Journals
Published: Mar 20, 2009
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