Genetic Factors Influencing Drug-Induced Liver Injury: Do They Have a Role in Prevention and Diagnosis?

Genetic Factors Influencing Drug-Induced Liver Injury: Do They Have a Role in Prevention and... Curr Hepatology Rep (2017) 16:258–264 DOI 10.1007/s11901-017-0363-9 DRUG-INDUCED LIVER INJURY (F BESSONE AND R ANDRADE, SECTION EDITORS) Genetic Factors Influencing Drug-Induced Liver Injury: Do They Have a Role in Prevention and Diagnosis? 1 1 1 Kathleen E. Clare & Michael H. Miller & John F. Dillon Published online: 7 August 2017 The Author(s) 2017. This article is an open access publication Abstract Drug-induced liver injury (DILI) is the leading cause of acute Purpose of Review The pathogenesis of DILI is currently un- liver failure in the UK and USA [1, 2]. It accounts for approx- known; however, research has shown strong genetic associa- imately 50% of all cases and is associated with high morbidity tions with some DILIs. This paper describes the variant alleles and mortality. One study found that patients with DILI- uncovered by GWAS and discusses their potential role as sus- associated jaundice had an 11.7% chance of progressing to ceptibility biomarkers. fulminant hepatic failure resulting in either death or transplan- Recent Findings An association with HLADRB1*15:01 and tation [3]. Although, paradoxically, this condition is rare, oc- amoxicillin/clavulanate DILI has been shown by a number of curring in only 1 in every 10,000 patients receiving DILI- research http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Hepatology Reports Springer Journals

Genetic Factors Influencing Drug-Induced Liver Injury: Do They Have a Role in Prevention and Diagnosis?

Loading next page...
 
/lp/springer_journal/genetic-factors-influencing-drug-induced-liver-injury-do-they-have-a-JKgSXae0OR
Publisher
Springer US
Copyright
Copyright © 2017 by The Author(s)
Subject
Medicine & Public Health; Hepatology
eISSN
2195-9595
D.O.I.
10.1007/s11901-017-0363-9
Publisher site
See Article on Publisher Site

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial