Genetic Factors Influencing Drug-Induced Liver Injury: Do They Have a Role in Prevention and Diagnosis?

Genetic Factors Influencing Drug-Induced Liver Injury: Do They Have a Role in Prevention and... Curr Hepatology Rep (2017) 16:258–264 DOI 10.1007/s11901-017-0363-9 DRUG-INDUCED LIVER INJURY (F BESSONE AND R ANDRADE, SECTION EDITORS) Genetic Factors Influencing Drug-Induced Liver Injury: Do They Have a Role in Prevention and Diagnosis? 1 1 1 Kathleen E. Clare & Michael H. Miller & John F. Dillon Published online: 7 August 2017 The Author(s) 2017. This article is an open access publication Abstract Drug-induced liver injury (DILI) is the leading cause of acute Purpose of Review The pathogenesis of DILI is currently un- liver failure in the UK and USA [1, 2]. It accounts for approx- known; however, research has shown strong genetic associa- imately 50% of all cases and is associated with high morbidity tions with some DILIs. This paper describes the variant alleles and mortality. One study found that patients with DILI- uncovered by GWAS and discusses their potential role as sus- associated jaundice had an 11.7% chance of progressing to ceptibility biomarkers. fulminant hepatic failure resulting in either death or transplan- Recent Findings An association with HLADRB1*15:01 and tation [3]. Although, paradoxically, this condition is rare, oc- amoxicillin/clavulanate DILI has been shown by a number of curring in only 1 in every 10,000 patients receiving DILI- research http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Hepatology Reports Springer Journals

Genetic Factors Influencing Drug-Induced Liver Injury: Do They Have a Role in Prevention and Diagnosis?

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Publisher
Springer US
Copyright
Copyright © 2017 by The Author(s)
Subject
Medicine & Public Health; Hepatology
eISSN
2195-9595
D.O.I.
10.1007/s11901-017-0363-9
Publisher site
See Article on Publisher Site

Abstract

Curr Hepatology Rep (2017) 16:258–264 DOI 10.1007/s11901-017-0363-9 DRUG-INDUCED LIVER INJURY (F BESSONE AND R ANDRADE, SECTION EDITORS) Genetic Factors Influencing Drug-Induced Liver Injury: Do They Have a Role in Prevention and Diagnosis? 1 1 1 Kathleen E. Clare & Michael H. Miller & John F. Dillon Published online: 7 August 2017 The Author(s) 2017. This article is an open access publication Abstract Drug-induced liver injury (DILI) is the leading cause of acute Purpose of Review The pathogenesis of DILI is currently un- liver failure in the UK and USA [1, 2]. It accounts for approx- known; however, research has shown strong genetic associa- imately 50% of all cases and is associated with high morbidity tions with some DILIs. This paper describes the variant alleles and mortality. One study found that patients with DILI- uncovered by GWAS and discusses their potential role as sus- associated jaundice had an 11.7% chance of progressing to ceptibility biomarkers. fulminant hepatic failure resulting in either death or transplan- Recent Findings An association with HLADRB1*15:01 and tation [3]. Although, paradoxically, this condition is rare, oc- amoxicillin/clavulanate DILI has been shown by a number of curring in only 1 in every 10,000 patients receiving DILI- research

Journal

Current Hepatology ReportsSpringer Journals

Published: Aug 7, 2017

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