Arch Virol (2010) 155:379–384 DOI 10.1007/s00705-009-0587-2 BRIEF REPORT Genetic diversity of Brazilian isolates of feline immunodeﬁciency virus • • • Bruno Marques Teixeira N. Logan J. C. M. Cruz • • • J. K. P. Reis P. E. Branda ˜ o L. J. Richtzenhain • • M. K. Hagiwara B. J. Willett M. J. Hosie Received: 27 March 2009 / Accepted: 10 December 2009 / Published online: 20 January 2010 Springer-Verlag 2010 We isolated feline immunodeﬁciency virus (FIV) from opportunistic infections , is a member of the family three adult domestic cats, originating from two open Retroviridae, genus Lentivirus. FIV-infected cats can shelters in Brazil. Viruses were isolated from PBMCs exhibit illnesses including gingivitis, stomatitis, lym- following co-cultivation with the feline T-lymphoblastoid phoma, neurological disorders and wasting [13, 28, 33]. cell line MYA-1. All ampliﬁed env gene products were The hallmark of FIV infection is a progressive reduction in cloned directly into pGL8 . The nucleic acid sequences the number of circulating CD4 lymphocytes, which ulti- MYA of seven clones were determined and then compared with mately results in an impairment of immunity, similar to those of previously described isolates. The sequences of all AIDS caused by human immunodeﬁciency
Archives of Virology – Springer Journals
Published: Mar 1, 2010
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