Review Incorporating Mouse Genome Mammalian Genome 13, 175–178 (2002). © Springer-Verlag New York Inc. 2002 DOI: 10.1007/s00335-001-4001-Y Genetic dissection of complex and quantitative traits: from fantasy to reality via a community effort 1 2 3 David W. Threadgill, Kent W. Hunter, Robert W. Williams Department of Genetics, CB#7264, Lineberger Comprehensive Cancer Center, Rm 11-109, University of North Carolina, Chapel Hill, North Carolina 27599, USA Laboratory of Population Genetics, DCEG/NCI/NIH, Bldg 41, Rm 702, 41 Library Drive, Bethesda, Maryland 20892, USA Center for Genomics and Bioinformatics, University of Tennessee Health Science Center, 858 Madison Avenue, Rm 101A, Memphis, Tennessee 38163, USA Received: 29 November 2001 / Accepted: 17 December 2001 During the previous century, isogenic lines of mice became one of recent resurgence witnessed for large-scale mutagenesis projects the major resources responsible for advancing biomedical and ge- with the formation of the International Mouse Mutagenesis Con- netic research. From humble beginnings in 1909, marked by deri- sortium (Nadeau et al. 2001). These large international programs vation of the DBA inbred strain by Clarence Little, founder of The have, by any measure, been tremendously successful and will pro- Jackson Laboratory, over 500 unique strains have been developed, vide years of resources
Mammalian Genome – Springer Journals
Published: Feb 12, 2014
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