Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/springer_journal/genetic-complexity-of-an-obesity-qtl-fob3-revealedby-detailed-genetic-pvgQRvt4PO
References (47)
-
T. Rankinen, L. Pérusse, S. Weisnagel, E. Snyder, Y. Chagnon, C. Bouchard (2002)
The human obesity gene map: the 2001 update.Obesity research, 10 3
-
I. Hastings, W. Hill (1989)
A note on the effect of different selection criteria on carcass composition in miceAnimal production, 48
-
G. Brockmann, M. Bevova (2002)
Using mouse models to dissect the genetics of obesity.Trends in genetics : TIG, 18 7
-
B. Taylor, L. Rowe (1987)
The congenital goiter mutation is linked to the thyroglobulin gene in the mouse.Proceedings of the National Academy of Sciences of the United States of America, 84 7
-
J. Hasegawa, K. Osatomi, R. Wu, K. Uyeda (1999)
A Novel Factor Binding to the Glucose Response Elements of Liver Pyruvate Kinase and Fatty Acid Synthase Genes*The Journal of Biological Chemistry, 274
-
G. Sharp, W. Hill, A. Robertson (1984)
Effects of selection on growth, body composition and food intake in mice. I. Responses in selected traits.Genetical research, 43 1
-
J. Cheverud, T. Vaughn, L. Pletscher, A. Peripato, Emily Adams, Christopher Erikson, Kelly King-Ellison (2001)
Genetic architecture of adiposity in the cross of LG/J and SM/J inbred miceMammalian Genome, 12
-
GENETIC COMPLEXITY OF THE FOB3 OBESITY QTL REGION -
(1989)
SAS/STAT User’s Guide, Version 6, 4th, ed, Volume 2 -
A. Law, A. Archibald (2000)
Farm Animal Genome DatabasesBriefings in bioinformatics, 1 2
-
A Darvasi (1997)
Interval-specific congenic strains (ISCS): an experimental design for mapping a QTL into a 1-centimorgan intervalMamm Genome, 8
-
S. Duthie, P. Taylor, L. Anderson, J. Cook, K. Eidne (1993)
Cloning and functional characterisation of the human TRH receptorMolecular and Cellular Endocrinology, 95
-
C. Haley, S. Knott (1992)
A simple regression method for mapping quantitative trait loci in line crosses using flanking markersHeredity, 69
-
S. Freytag, Tim Geddes (1992)
Reciprocal Regulation of Adipogenesis by Myc and C/EBPαScience, 256
-
David West, J. Goudey-Lefevre, B. York, Gary Truett (1994)
Dietary obesity linked to genetic loci on chromosomes 9 and 15 in a polygenic mouse model.The Journal of clinical investigation, 94 4
-
Y. Chagnon, T. Rankinen, E. Snyder, S. Weisnagel, L. Pérusse, C. Bouchard (2003)
The human obesity gene map: the 2002 update.Obesity research, 11 3
-
K. Kosuga, S. Hata, T. Osumi, J. Sakakibara, T. Ono (1995)
Nucleotide sequence of a cDNA for mouse squalene epoxidase.Biochimica et biophysica acta, 1260 3
-
P. Keightley, K. Morris, A. Ishikawa, V. Falconer, Fiona Oliver (1998)
Test of candidate gene–quantitative trait locus association applied to fatness in miceHeredity, 81
-
G. Churchill, R. Doerge (1994)
Empirical threshold values for quantitative trait mapping.Genetics, 138 3
-
S Hofmann, P Lichtner, S Schuffenhauer, KD Gerbitz, T Meitinger (1998)
Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22→;q23 and 5ql4 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16pl2 and 13q14→;q21 by FISH and radiation hybrid mapping 141Cytogenet Cell Genet, 83
-
E. Lander, P. Green (1987)
Construction of multilocus genetic linkage maps in humans.Proceedings of the National Academy of Sciences of the United States of America, 84 8
-
L Bünger, WG Hill (1999)
Inbred lines of mice derived from long-term divergent selection on fat content and body weightMamm Genome, 10
-
C. Ikeobi, John Woolliams, D. Morrice, A. Law, D. Windsor, Dave Burt, P. Hocking (2002)
Quantitative trait loci affecting fatness in the chicken.Animal genetics, 33 6
-
(1992)
Cloning and functional characterisation of the human TRH receptor Reciprocal regulation of adipogenesis by Myc and C/EBP alpha -
K. Morris, A. Ishikawa, P. Keightley (1999)
Quantitative trait loci for growth traits in C57BL/6J × DBA/2J miceMammalian Genome, 10
-
F. Brien, G. Sharp, W. Hill, A. Robertson (1984)
Effects of selection on growth, body composition and food intake in mice. II. Correlated responses in reproduction.Genetical research, 44 1
-
(1999)
Quantitative trait loci for growth traits in C57BL/6J · DBA/2] mice -
A. Sewalem, DM Morrice, A. Law, D. Windsor, CS Haley, CO Ikeobi, DW Burt, PM Hocking (2002)
Mapping of quantitative trait loci for body weight at three, six, and nine weeks of age in a broiler layer cross.Poultry science, 81 12
-
D. Pomp (1997)
Genetic Dissection of Obesity in Polygenic Animal ModelsBehavior Genetics, 27
-
J. Cheverud, E. Routman, E. Routman, F. Duarte, B. vanSwinderen, K. Cothran, C. Perel (1996)
Quantitative trait loci for murine growth.Genetics, 142 4
-
J. Kaam, M. Groenen, H. Bovenhuis, A. Veenendaal, A. Vereijken, J. Arendonk (1999)
Whole genome scan in chickens for quantitative trait loci affecting growth and feed efficiency.Poultry science, 78 1
-
(1995)
Identification of four chromosomal 480 I.M. STYLIANOU ET AL: GENETIC COMPLEXITY OF THE FOB3 OBESITY QTL REGION loci determining obesity in a multifactorial mouse model -
B York, K Lei, DB West (1996)
Sensitivity to dietary obesity linked to a locus on chromosome 15 in a CAST/Ei × C57BL/6J F2 intercrossMamm Genome, 7
-
M. Mehrabian, P. Wen, J. Fisler, R. Davis, A. Lusis (1998)
Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model.The Journal of clinical investigation, 101 11
-
J. Gu, X. Lin, D. Wells (1996)
The human B22 subunit of the NADH-ubiquinone oxidoreductase maps to the region of chromosome 8 involved in branchio-oto-renal syndrome.Genomics, 35 1
-
L. Bünger, Juergen Forsting, Katharine McDonald, S. Horvat, J. Duncan, S. Hochscheid, C. Baile, W. Hill, J. Speakman (2003)
Long‐term divergent selection on body fatness in mice indicates a regulation system that is independent of leptin production and receptionThe FASEB Journal, 17
-
D. Drolet, K. Scully, D. Simmons, M. Wegner, K. Chu, L. Swanson, M. Rosenfeld (1991)
TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins.Genes & development, 5 10
-
Craig Warden, J. Fisler, Susan Shoemaker, P. Wen, Karen Svenson, Mario Pace, A. Lusis (1995)
Identification of four chromosomal loci determining obesity in a multifactorial mouse model.The Journal of clinical investigation, 95 4
-
S. Horvat, L. Bünger, V. Falconer, Pamela Mackay, A. Law, G. Bulfield, P. Keightley (2000)
Mapping of obesity QTLs in a cross between mouse lines divergently selected on fat contentMammalian Genome, 11
-
P. Laird, A. Zijderveld, K. Linders, Michael Rudnicki, R. Jaenisch, A. Berns (1991)
Simplified mammalian DNA isolation procedure.Nucleic acids research, 19 15
-
M. Légaré, F. Bartlett, W. Frankel (2000)
A major effect QTL determined by multiple genes in epileptic EL mice.Genome research, 10 1
-
J. Christians, V. Bingham, Fiona Oliver, Thomas Heath, P. Keightley (2003)
Characterization of a QTL affecting skeletal size in miceMammalian Genome, 14
-
P. Visscher, Robin Thompson, C. Haley (1996)
Confidence intervals in QTL mapping by bootstrapping.Genetics, 143 2
-
P. Visscher, Chris Haley (1996)
Detection of putative quantitative trait loci in line crosses under infinitesimal genetic modelsTheoretical and Applied Genetics, 93
-
(2003)
Long-term divergent selection on fatness in mice indicates a regulation system independent of leptin production and reception -
S. Cases, S. Smith, Y. Zheng, H. Myers, S. Lear, E. Sande, S. Novak, C. Collins, C. Welch, A. Lusis, S. Erickson, Robert Farese (1998)
Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis.Proceedings of the National Academy of Sciences of the United States of America, 95 22
-
Y. Wang, P. Kowalski, I. Thalmann, D. Ornitz, D. Mager, R. Thalmann (1998)
Otoconin-90, the mammalian otoconial matrix protein, contains two domains of homology to secretory phospholipase A2.Proceedings of the National Academy of Sciences of the United States of America, 95 26
- Publisher
- Springer Journals
- Copyright
- Copyright © 2004 by Springer-Verlag
- Subject
- Philosophy
- ISSN
- 0938-8990
- eISSN
- 1432-1777
- DOI
- 10.1007/s00335-004-3039-z
- pmid
- 15181539
- Publisher site
- See Article on Publisher Site
Abstract
Obesity is proving to be a serious health concern in the developed world as well as an unwanted component of growth in livestock production. While recent advances in genetics have identified a number of monogenic causes of obesity, these are responsible for only a small proportion of human cases of obesity. By divergent selection for high and low fat content over 60 generations, we have created Fat (F) and Lean (L) lines of mice that represent a model of polygenic obesity similar to the situation in human populations. From previous crosses of these lines, four body fat quantitative trait loci (QTL) were identified. We have created congenic lines (Fchr15L), by recurrent marker-assisted backcrossing, to introgress the QTL region with the highest LOD score, Fob3 on Chr 15, from the L-Iine into the F-line background. We have further mapped this QTL by progeny testing of recombinants, produced from crosses between the F-line and congenic Fchrl5L mice, showing that the Fob3 QTL region is a composite of at least two smaller effect QTL—the proximal QTL Fob3a is a late-onset obesity QTL, whereas the distal Fob3b is an early-onset obesity QTL.
Journal
Mammalian Genome – Springer Journals
Published: Jan 1, 2004