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Genetic bases of the repertoire of immunoglobulins in application to diagnostics of clonality of B-cell lymphoid populations

Genetic bases of the repertoire of immunoglobulins in application to diagnostics of clonality of... Molecular mechanisms underlying the formation of B-cell lymphomas in connection with processes associated with the maturation of B-lymphocytes are reviewed. The currently used diagnostic methods do not always distinguish lymphomas from reactive changes of the lymphoid tissue. The principle of the molecular genetic method of clonality detection in lymphocyte populations, technical problems, and the strategy of its application in clinical diagnostics of lymphomas are described in detail. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Genetic bases of the repertoire of immunoglobulins in application to diagnostics of clonality of B-cell lymphoid populations

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References (36)

Publisher
Springer Journals
Copyright
Copyright © 2011 by Pleiades Publishing, Ltd.
Subject
Biomedicine; Human Genetics ; Microbial Genetics and Genomics; Animal Genetics and Genomics
ISSN
1022-7954
eISSN
1608-3369
DOI
10.1134/S1022795411050188
Publisher site
See Article on Publisher Site

Abstract

Molecular mechanisms underlying the formation of B-cell lymphomas in connection with processes associated with the maturation of B-lymphocytes are reviewed. The currently used diagnostic methods do not always distinguish lymphomas from reactive changes of the lymphoid tissue. The principle of the molecular genetic method of clonality detection in lymphocyte populations, technical problems, and the strategy of its application in clinical diagnostics of lymphomas are described in detail.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Jun 16, 2011

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