Genetic association of ADRA2A and ADRB3 genes with metabolic syndrome among the Tatars

Genetic association of ADRA2A and ADRB3 genes with metabolic syndrome among the Tatars An association study was performed for genetic polymorphisms in ADRB3 (rs4994) and ADRA2A (rs1800544, rs553668) genes to estimate their effect on quantitative parameters, including glucose, insulin, and HOMA-IR index in women from the Tatar population of Russia. It has been shown that CT and CC are associated with metabolic syndrome and increased insulin. It was shown that ADRA2A (rs1800544) gene polymorphism was associated with high levels of insulin and an increased HOMA-IR index in GG- and GC-genotype carriers. Polymorphic locus rs553668 of gene ADRA2A is associated with increased glucose in CT- and TT-genotype carriers. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Genetic association of ADRA2A and ADRB3 genes with metabolic syndrome among the Tatars

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Publisher
Pleiades Publishing
Copyright
Copyright © 2015 by Pleiades Publishing, Inc.
Subject
Biomedicine; Human Genetics; Animal Genetics and Genomics; Microbial Genetics and Genomics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1134/S1022795415070066
Publisher site
See Article on Publisher Site

Abstract

An association study was performed for genetic polymorphisms in ADRB3 (rs4994) and ADRA2A (rs1800544, rs553668) genes to estimate their effect on quantitative parameters, including glucose, insulin, and HOMA-IR index in women from the Tatar population of Russia. It has been shown that CT and CC are associated with metabolic syndrome and increased insulin. It was shown that ADRA2A (rs1800544) gene polymorphism was associated with high levels of insulin and an increased HOMA-IR index in GG- and GC-genotype carriers. Polymorphic locus rs553668 of gene ADRA2A is associated with increased glucose in CT- and TT-genotype carriers.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Jul 25, 2015

References

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