Genetic and physical mapping of the mouse host resistance locus Lgn1

Genetic and physical mapping of the mouse host resistance locus Lgn1 Short Communications Mammalian Genome 8,682-685 (1997). 9 Springer-Vedag New York Inc. 1997 Genetic and physical mapping of the mouse host resistance locus Lgnl Eduarto Diez, 1 Marie-Claire Beckers, z Eric Ernst, z Christine J. DiDonato, 3 Louise R. Simard, 3 Celine Morissette, 4 Francine Gervais, 4 Shin-lchi Yoshida, s Philippe Gros l'z lDepartment of Biochemistry, McGill University, Montreal, Canada, H3G-1Y6 2Department of Genetics, Faculty of Veterinary Medicine, University of Liege, 4000 Liege, Belgium 3Genetique Medicale, Hopital Salnte-Justine, Montreal, Quebec, Canada, H3T-1C5 4Center for the Study of Host Resistance, Montreal General Hospital, Montreal, Canada, H3G 1A4 5Department of Microbiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, 807 Japan Received: 26 March 1997 / Accepted: 26 April 1997 Legionella pneumophila is a strict intracellular pathogen that ABA backcross panel to reduce the Lgnl genetic interval to 1.0 causes an acute form of pneumonia in humans, called Legion- cM, as D13Mit146/D13Die6-(0.6 cM)-Lgn1/D13Mit37-(0.4 naires' disease (Fraser et al. 1977; McDade et al. 1977; Glick et al. cM)-D13Die7a/D13Dielb/D13Die3-(1.2 cM)-D13Mit70. The 1978). L. pneumophila enters human macrophages through a nonrecombinant interval for Lgnl is homologous to the human unique "coiling phagocytosis" mechanism (Horwitz 1984) and Spinal Muscular Atrophy (SMA) gene region and Mammalian Genome Springer Journals

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Copyright © 1997 by Springer-Verlag
Life Sciences; Cell Biology; Anatomy; Zoology
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