Genetic and Chromosomal Control of Development

Genetic and Chromosomal Control of Development The last decade has been characterized by extraordinary progress in studies of the molecular mechanisms underlying the gene control of development: complexes of genes with a hierarchic principle of functioning have been identified, evolutionary-conservative systems of genes have been studied that ensure the transmembrane regulatory signaling between cells and play a key role in morphogenesis, and a concept of gene networks that coordinate gene interaction was introduced. Note that temporal and tissue-specific parameters of gene expression are correctly realized only in terms of chromosomes and are largely determined by the gene position on a chromosome and in the interphase nucleus. The epigenetic inheritance of gene status in cell generations is realized at the chromosomal level alone due to the cellular or chromosomal memory. This ontogenetic memory is an immanent property of a chromosome and cis-regulation plays a key role in its maintenance. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Developmental Biology Springer Journals

Genetic and Chromosomal Control of Development

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Publisher
Kluwer Academic Publishers-Plenum Publishers
Copyright
Copyright © 2004 by MAIK “Nauka/Interperiodica”
Subject
Life Sciences; Animal Anatomy / Morphology / Histology
ISSN
1062-3604
eISSN
1608-3326
D.O.I.
10.1023/B:RUDO.0000036709.76016.73
Publisher site
See Article on Publisher Site

Abstract

The last decade has been characterized by extraordinary progress in studies of the molecular mechanisms underlying the gene control of development: complexes of genes with a hierarchic principle of functioning have been identified, evolutionary-conservative systems of genes have been studied that ensure the transmembrane regulatory signaling between cells and play a key role in morphogenesis, and a concept of gene networks that coordinate gene interaction was introduced. Note that temporal and tissue-specific parameters of gene expression are correctly realized only in terms of chromosomes and are largely determined by the gene position on a chromosome and in the interphase nucleus. The epigenetic inheritance of gene status in cell generations is realized at the chromosomal level alone due to the cellular or chromosomal memory. This ontogenetic memory is an immanent property of a chromosome and cis-regulation plays a key role in its maintenance.

Journal

Russian Journal of Developmental BiologySpringer Journals

Published: Sep 19, 2004

References

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