The last decade has been characterized by extraordinary progress in studies of the molecular mechanisms underlying the gene control of development: complexes of genes with a hierarchic principle of functioning have been identified, evolutionary-conservative systems of genes have been studied that ensure the transmembrane regulatory signaling between cells and play a key role in morphogenesis, and a concept of gene networks that coordinate gene interaction was introduced. Note that temporal and tissue-specific parameters of gene expression are correctly realized only in terms of chromosomes and are largely determined by the gene position on a chromosome and in the interphase nucleus. The epigenetic inheritance of gene status in cell generations is realized at the chromosomal level alone due to the cellular or chromosomal memory. This ontogenetic memory is an immanent property of a chromosome and cis-regulation plays a key role in its maintenance.
Russian Journal of Developmental Biology – Springer Journals
Published: Sep 19, 2004
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