Short Communications Incorporating Mouse Genome Mammalian Genome 11, 926–929 (2000). © Springer-Verlag New York Inc. 2000 DOI: 10.1007/s003350010171 Genes encoding troponin I and troponin T are organized as three paralogous pairs in the mouse genome 1 1 1 2 3 Paul J.R. Barton, Antony J. Mullen, Martin E. Cullen, Gurtej K. Dhoot, Dominique Simon-Chazottes, Jean-Louis Gue ´net Cardiothoracic Surgery, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, UK Department of Basic Sciences, Royal Veterinary College, Royal College Street, London NW1 0TU, UK Unite´de Ge ´ne ´tique des Mammife `res, Institut Pasteur, 25 Rue du Dr Roux, 75724 Paris Cedex 15, France Received: 16 February 1999 / Accepted: 24 May 2000 The troponin complex is located on the thin filament of striated gene would lie immediately upstream of, and head to tail with muscle and is the calcium-sensitive molecular switch that regulates Tnnt1. This was confirmed to be the case in three independent striated muscle contraction in response to alterations in intracellu- PAC genomic clones identified by hybridization screening with lar calcium concentration. It is composed of three subunits: tropo- the slow skeletal troponin T cDNA (see Fig. 1). Restriction digests nin C,
Mammalian Genome – Springer Journals
Published: Feb 27, 2014
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