Review Incorporating Mouse Genome Mammalian Genome 9, 683–687 (1998). © Springer-Verlag New York Inc. 1998 Genes, cells and organs: recent developments in the molecular genetics of mammalian sex determination Andy Greenfield MRC Mammalian Genetics Unit, Harwell, Chilton, Oxfordshire OX11 ORD, UK Received: 28 April 1998 / Accepted: 7 May 1998 Introduction from anterior to posterior, but the cellular basis of this dynamic pattern of transcription is not yet known (Swain et al. 1998). The The frequency of use of the expression ‘‘genetic pathway’’ tends exact function of the SRY protein is also unclear, but DNA bind- to obscure the fact that few hierarchical systems of gene regulation ing, mediated by its HMG-box domain, results in pronounced have been described in mammals. In addition, focusing on such DNA bending which is critical to its sex determining function pathways as a means of determining cell fate in higher organisms (Pontiggia et al. 1994). Thus, SRY is likely to act as transcriptional sometimes results in a linear, one-dimensional conception of bi- modulator. ology: we may forget the dynamic properties of cells which are How is the precise pattern of SRY transcription regulated, and crucial in pattern formation and organogenesis. Recent studies on
Mammalian Genome – Springer Journals
Published: Sep 1, 1998
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