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(1995)
Mouse Genetics (New York: Oxford University
The shaded areas indicate polymorphic stretches of SNP counts greater than 10
J. Černý, R. Mcalack, M. Sajid, H. Friedman (1971)
Genetic differences in the immunocyte response of mice to separate determinants on one bacterial antigen.Nature: New biology, 230 16
J. Rinn, M. Snyder (2005)
Sexual dimorphism in mammalian gene expression.Trends in genetics : TIG, 21 5
John Storey (2002)
A direct approach to false discovery ratesJournal of the Royal Statistical Society: Series B (Statistical Methodology), 64
L. Thaete, M. Nesbitt, A. Malkinson (1991)
Lung adenoma structure among inbred strains of mice: the pulmonary adenoma histologic type (Pah) genes.Cancer letters, 61 1
D. Mosier (1986)
Animal models for retrovirus-induced immunodeficiency disease.Immunological investigations, 15 3
O. Kristiansen, Z. Larsen, F. Pociot (2000)
CTLA-4 in autoimmune diseases – a general susceptibility gene to autoimmunity?Genes and Immunity, 1
J. Marshall, J. Mu, Y. Cheah, M. Nesbitt, W. Frankel, B. Paigen (2004)
The AXB and BXA set of recombinant inbred mouse strainsMammalian Genome, 3
P. Petkov, Yueming Ding, Megan Cassell, Weidong Zhang, Gunjan Wagner, E. Sargent, S. Asquith, Victor Crew, Kevin Johnson, P. Robinson, V. Scott, M. Wiles (2004)
An efficient SNP system for mouse genome scanning and elucidating strain relationships.Genome research, 14 9
J. Singer, Annie Hill, L. Burrage, Keith Olszens, Junghan Song, M. Justice, William O'Brien, D. Conti, J. Witte, E. Lander, J. Nadeau (2004)
Genetic Dissection of Complex Traits with Chromosome Substitution Strains of MiceScience, 304
Hao Wu, M. Kerr, X. Cui, G. Churchill (2003)
MAANOVA: A Software Package for the Analysis of Spotted cDNA Microarray Experiments
Gongming Yang, K. Kitagawa, K. Matsushita, T. Mabuchi, Y. Yagita, T. Yanagihara, M. Matsumoto (1997)
C57BL/6 strain is most susceptible to cerebral ischemia following bilateral common carotid occlusion among seven mouse strains: selective neuronal death in the murine transient forebrain ischemiaBrain Research, 752
J. Walton, R. Frisina, Lauren Meierhans (1995)
Sensorineural hearing loss alters recovery from short-term adaptation in the C57BL/6 mouseHearing Research, 88
Points in green represent probe sets related to genes that are involved in muscle contraction, muscle development and hypoxia
G. Churchill (2004)
Using ANOVA to analyze microarray data.BioTechniques, 37 2
J. Mu, J. Naggert, P. Nishina, Y. Cheah, B. Paigen (2004)
Strain distribution pattern in AXB and BXA recombinant inbred strains for loci on murine Chromosomes 10, 13, 17, and 18Mammalian Genome, 4
JB Storer (1966)
Longevity and gross pathology at death in 22 inbred strains of miceJ Gerontol, 21
L. Gautier, L. Cope, B. Bolstad, R. Irizarry (2004)
affy - analysis of Affymetrix GeneChip data at the probe levelBioinformatics, 20 3
C. Tankersley, Robert Fitzgerald, S. Kleeberger (1994)
Differential control of ventilation among inbred strains of mice.The American journal of physiology, 267 5 Pt 2
E. Chesler, Lu Lu, S. Shou, Yanhua Qu, Jing Gu, Jintao Wang, H. Hsu, J. Mountz, Nicole Baldwin, M. Langston, D. Threadgill, K. Manly, Robert Williams (2005)
Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system functionNature Genetics, 37
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler (2002)
Gene ontology: tool for the unification of biology. The Gene Ontology ConsortiumNature Genetics, 25
L. Moore, J. Burt (1994)
Selective block of gap junction channel expression with connexin-specific antisense oligodeoxynucleotides.The American journal of physiology, 267 5 Pt 1
M. Rebuffé-Scrive, R. Surwit, M. Feinglos, Cynthia Kuhn, J. Rodin (1993)
Regional fat distribution and metabolism in a new mouse model (C57BL/6J) of non-insulin-dependent diabetes mellitus.Metabolism: clinical and experimental, 42 11
X. Cui, J. Hwang, J. Qiu, Natalie Blades, G. Churchill (2005)
Improved statistical tests for differential gene expression by shrinking variance components estimates.Biostatistics, 6 1
J. Actor, M. Olsen, C. Jagannath, R. Hunter (1999)
Relationship of survival, organism containment, and granuloma formation in acute murine tuberculosis.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 19 10
Fumihiro Sugiyama, Gary Churchill, David Higgins, C. Johns, Konstatinos Makaritsis, Haralambos Gavras, Beverly Paigen (2001)
Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci.Genomics, 71 1
R. Irizarry, B. Bolstad, F. Collin, L. Cope, Bridget Hobbs, T. Speed (2003)
Summaries of Affymetrix GeneChip probe level data.Nucleic acids research, 31 4
J. Storer (1966)
Longevity and gross pathology at death in 22 inbred mouse strains.Journal of gerontology, 21 3
Jian-Hua Qiao, Michael Fishbein, L. Demer, A. Lusis (1995)
Genetic determination of cartilaginous metaplasia in mouse aorta.Arteriosclerosis, thrombosis, and vascular biology, 15 12
有田 浩一朗, 伊平 弥生, 朝田 芳信 (2005)
Strain distribution pattern を用いたマウス癒合根成因に対しての候補染色体の特定, 43
P. Hamet, Z. Pausova, P. Dumas, Y. Sun, J. Tremblay, M. Pravenec, J. Kuneš, D. Křenová, V. Křen (1998)
Newborn and adult recombinant inbred strains: a tool to search for genetic determinants of target organ damage in hypertension.Kidney international, 53 6
R. Irizarry, Bridget Hobbs, F. Collin, Y. Beazer-Barclay, Kristen Antonellis, U. Scherf, T. Speed (2003)
Exploration, normalization, and summaries of high density oligonucleotide array probe level data.Biostatistics, 4 2
D. Myers, H. Meier, R. Huebner (1970)
Prevalence of murine C-type RNA virus group specific antigen in inbred strains of mice.Life sciences. Pt. 2: Biochemistry, general and molecular biology, 9 18
A. Malkinson, M. Nesbitt, E. Skamene (1985)
Susceptibility to urethan-induced pulmonary adenomas between A/J and C57BL/6J mice: use of AXB and BXA recombinant inbred lines indicating a three-locus genetic model.Journal of the National Cancer Institute, 75 5
W. Hoag (1963)
SPONTANEOUS CANCER IN MICE *Annals of the New York Academy of Sciences, 108
M. Lipoldová, M. Svobodová, M. Krulová, H. Havelková, J. Badalová, E. Nohýnková, V. Holan, A. Hart, P. Volf, P. Demant (2000)
Susceptibility to Leishmania major infection in mice: multiple loci and heterogeneity of immunopathological phenotypesGenes and Immunity, 1
C. Sadarangani, E. Skamene, P. Kongshavn (1980)
Cellular basis for genetically determined enhanced resistance of certain mouse strains to listeriosisInfection and Immunity, 28
M. Kerr, Mitchell Martin, Gary Churchill (2000)
Analysis of Variance for Gene Expression Microarray DataJournal of computational biology : a journal of computational molecular cell biology, 7 6
(2006)
Labeled edges (A – H) are discussed in the main text
J. Plant, J. Blackwell, A. O’Brien, D. Bradley, A. Glynn (1982)
Are the Lsh and Ity disease resistance genes at one locus on mouse chromosome 1?Nature, 297
LM Silver (1995)
Mouse Genetics
M. Ashburner, C. Ball, J. Blake, D. Botstein, Heather Butler, J. Cherry, A. Davis, K. Dolinski, S. Dwight, J. Eppig, M. Harris, D. Hill, L. Issel-Tarver, A. Kasarskis, S. Lewis, J. Matese, J. Richardson, M. Ringwald, G. Rubin, G. Sherlock (2000)
Gene Ontology: tool for the unification of biologyNature Genetics, 25
Representative patterns of normalized expression values for CSS and parental strains
(2006)
Functional categories shared among CSS strains. Shown are four functional groupings of interest out of a total of 140 manually assembled gene categories taken from GO-term Shockley and Churchill
L. Matesic, E. Niemitz, A. Maio, R. Reeves (2000)
Quantitative trait loci modulate neutrophil infiltration in the liver during LPS‐induced inflammationThe FASEB Journal, 14
E. Mills, C. Kuhn, M. Feinglos, R. Surwit (1993)
Hypertension in CB57BL/6J mouse model of non-insulin-dependent diabetes mellitus.The American journal of physiology, 264 1 Pt 2
Douglas Hosack, Glynn Dennis, Brad Sherman, H. Lane, R. Lempicki (2003)
Identifying biological themes within lists of genes with EASEGenome Biology, 4
Scatterplots of normalized expression values for the B versus B.A12 comparison. Points in red represent probe sets that map to genes involved in digestion of carbohydrates and proteins
A. Cowley, R. Roman, H. Jacob (2004)
Application of chromosomal substitution techniques in gene‐function discoveryThe Journal of Physiology, 554
M. Wills-Karp, S. Ewart (1997)
The genetics of allergen-induced airway hyperresponsiveness in mice.American journal of respiratory and critical care medicine, 156 4 Pt 2
R. Surwit, R. Surwit, M. Feinglos, M. Feinglos, J. Rodin, J. Rodin, A. Sutherland, A. Sutherland, A. Petro, A. Petro, E. Opara, E. Opara, C. Kuhn, C. Kuhn, M. Rebuffé-Scrive, M. Rebuffé-Scrive (1995)
Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice.Metabolism: clinical and experimental, 44 5
M. Festing (1969)
Inbred Mice in ResearchNature, 221
(2006)
Differential Expression in Mouse Liver for pooled and individual samples from
M. Ho, C. Post, L. Donahue, H. Lidov, R. Bronson, H. Goolsby, Simon Watkins, G. Cox, Robert Brown (2004)
Disruption of muscle membrane and phenotype divergence in two novel mouse models of dysferlin deficiency.Human molecular genetics, 13 18
D. Shih, Lingjie Gu, S. Hama, Yu-Rong Xia, M. Navab, A. Fogelman, A. Lusis (1996)
Genetic-dietary regulation of serum paraoxonase expression and its role in atherogenesis in a mouse model.The Journal of clinical investigation, 97 7
A. Cervino, Guoya Li, Steve Edwards, Jun Zhu, C. Laurie, G. Tokiwa, P. Lum, Susanna Wang, L. Castellani, A. Lusis, Sonia Carlson, A. Sachs, E. Schadt (2005)
Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels.Genomics, 86 5
A. Fortin, Eduardo Diez, D. Rochefort, L. Laroche, Danielle Malo, Danielle Malo, Guy Rouleau, Guy Rouleau, Philippe Gros, Philippe Gros, Emil Skamene, Emil Skamene (2001)
Recombinant congenic strains derived from A/J and C57BL/6J: a tool for genetic dissection of complex traits.Genomics, 74 1
G. Parmigiani, E. Garrett, R. Irizarry, S. Zeger (2003)
The Analysis of Gene Expression Data: An Overview of Methods and Software
J. Nadeau, J. Singer, A. Matin, E. Lander (2000)
Analysing complex genetic traits with chromosome substitution strainsNature Genetics, 24
M. Kaye, R. Kusy (1995)
Genetic lineage, bone mass, and physical activity in mice.Bone, 17 2
M. Kerr, G. Churchill (2001)
Bootstrapping cluster analysis: Assessing the reliability of conclusions from microarray experimentsProceedings of the National Academy of Sciences of the United States of America, 98
M. Stevenson, P. Kongshavn, E. Skamene (1981)
Genetic linkage of resistance to Listeria monocytogenes with macrophage inflammatory responses.Journal of immunology, 127 2
C. Goodrick (1975)
Life-span and the inheritance of longevity of inbred mice.Journal of gerontology, 30 3
H. Curtis (1971)
Genetic factors in aging.Advances in genetics, 16
D. Fleiszer, J. Hilgers, E. Skamene (1988)
Multigenic control of colon carcinogenesis in mice treated with 1,2-dimethylhydrazine.Current topics in microbiology and immunology, 137
C. Wade, E. Kulbokas, Andrew Kirby, M. Zody, J. Mullikin, E. Lander, K. Lindblad-Toh, M. Daly (2002)
The mosaic structure of variation in the laboratory mouse genomeNature, 420
An analysis of transcriptional variation in the liver using a panel of B.A chromosome substitution strains identified 4209 transcripts that are differentially expressed relative to the C57BL/6J background and 1010 transcripts that are differentially expressed between C57BL/6J and A/J strains. A subset of these strains (substituting Chromosomes 1, 6, and 15) was used to identify 386 additional differentially expressed transcripts in the kidney. Approximately 15% of differentially expressed transcripts are located on the substituted chromosome. These cis-QTL are codirectionally expressed with the donor strain A/J. By comparison, trans-regulated loci comprise 85% of differentially expressed transcripts, often show opposite direction of change compared with A/J, and can be regulated by multiple chromosome substitutions. Gene expression differences in this study provide evidence for transgressive segregation: Only 438 of 4209 QTL in liver were inside the parental range. By combining QTL data with known biological functions, we were able to identify physiologic pathways altered in multiple strains. In many cases the same pathways were altered by multiple distinct chromosome substitutions. Taken together, these results suggest that widespread epistatic background effects may result in complex and overlapping transcriptional relationships among different chromosome substitution strains. Transcriptional profiling of chromosome substitution strains reveals a complex genetic architecture of transcriptional regulation.
Mammalian Genome – Springer Journals
Published: Jun 12, 2006
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