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DL Guberski, VA Thomas, WR Shek, A. Like, ES Handler, Aldo Rossini, JE Wallace, RM Welsh (1991)
Induction of type I diabetes by Kilham's rat virus in diabetes-resistant BB/Wor rats.Science, 254 5034
Kewu Huang, R. Rabold, B. Schofield, W. Mitzner, C. Tankersley (2007)
Age-dependent changes of airway and lung parenchyma in C57BL/6J mice.Journal of applied physiology, 102 1
P. Konig, Simon Godfrey (1973)
Prevalence of exercise-induced bronchial lability in families of children with asthma.Archives of Disease in Childhood, 48
K. Pelkonen, O. Hänninen (1997)
Cytotoxicity and biotransformation inducing activity of rodent beddings: a global survey using the Hepa-1 assay.Toxicology, 122 1-2
R. Itah, J. Tal, C. Davis (2004)
Host Cell Specificity of Minute Virus of Mice in the Developing Mouse EmbryoJournal of Virology, 78
A. Jackson, M. Murphy, J. Rassulo, B. Celli, R. Ingram (2004)
Deep breath reversal and exponential return of methacholine-induced obstruction in asthmatic and nonasthmatic subjects.Journal of applied physiology, 96 1
L. Lundblad, C. Irvin, A. Adler, J. Bates (2002)
A reevaluation of the validity of unrestrained plethysmography in mice.Journal of applied physiology, 93 4
B. Kile, Cammy Mason-Garrison, M. Justice (2003)
Sex and strain-related differences in the peripheral blood cell values of inbred mouse strainsMammalian Genome, 14
J. Orehek (1987)
Effects of volume history during spontaneous and acutely induced air-flow obstruction in asthma.The American review of respiratory disease, 136 3
David Brown, R. Welsh, A. Like (1993)
Infection of peripancreatic lymph nodes but not islets precedes Kilham rat virus-induced diabetes in BB/Wor ratsJournal of Virology, 67
(2001)
Functional identification of neural genes. In: Chin HR, Moldin SO (eds.) Methods in Genomic Neuroscience
LH Pinto, JS Takahashi (1999)
Handbook of Molecular-Genetic Techniques for Brain and Behavioral Research (Techniques in the Behavioral and Neural Sciences)
L. Pinto, J. Takahashi (1999)
Chapter 2.1.7 Genetic dissection of mouse behavior using induced mutagenesisTechniques in The Behavioral and Neural Sciences, 13
R. Balling (2001)
ENU mutagenesis: analyzing gene function in mice.Annual review of genomics and human genetics, 2
H. Chin, S. Moldin (2001)
Methods in Genomic Neuroscience
C. Tankersley, R. Rabold, W. Mitzner (1999)
Differential lung mechanics are genetically determined in inbred murine strains.Journal of applied physiology, 86 6
J. Takahashi, Lawrence Pinto, M. Vitaterna (1994)
Forward and reverse genetic approaches to behavior in the mouse.Science, 264 5166
L. Peters, Eleanor Cheever, Heather Ellis, Phyllis Magnani, K. Svenson, R. Smith, M. Bogue (2002)
Large-scale, high-throughput screening for coagulation and hematologic phenotypes in mice.Physiological genomics, 11 3
N. Withers, Lorraine Low, S. Holgate, J. Clough (1998)
The natural history of respiratory symptoms in a cohort of adolescents.American journal of respiratory and critical care medicine, 158 2
M. Dowell, O. Lakser, W. Gerthoffer, J. Fredberg, G. Stelmack, A. Halayko, J. Solway, R. Mitchell (2005)
Latrunculin B increases force fluctuation-induced relengthening of ACh-contracted, isotonically shortened canine tracheal smooth muscle.Journal of applied physiology, 98 2
E. Kaliste, M. Linnainmaa, T. Meklin, E. Torvinen, A. Nevalainen (2004)
The bedding of laboratory animals as a source of airborne contaminantsLaboratory Animals, 38
(2002)
Becklake MR (2002) Risk factors for bronchial hyperresponsiveness in late childhood and early adolescence
R. Törrönen, K. Pelkonen, S. Kärenlampi (1989)
Enzyme-inducing and cytotoxic effects of wood-based materials used as bedding for laboratory animals. Comparison by a cell culture study.Life sciences, 45 6
JS Takahashi, LH Pinto, MH Vitatema (1994)
Forward and reverse genetic approaches to behavior in the mouse [see comments]Science, 264
J. Bates, C. Irvin, V. Brusasco, J. Drazen, J. Fredberg, S. Loring, D. Eidelman, M. Ludwig, P. Macklem, James Martin, J. Milic‐Emili, Z. Hantos, R. Hyatt, S. Lai-Fook, Alan Leff, J. Solway, K. Lutchen, B. Suki, W. Mitzner, P. Paré, N. Pride, P. Sly (2004)
The use and misuse of Penh in animal models of lung disease.American journal of respiratory cell and molecular biology, 31 3
Bjornson Cl, I. Mitchell (2000)
Gender differences in asthma in childhood and adolescence.The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia, 3 8
Roberto de MARCO, F. Locatelli, Jordy Sunyer, P. Burney (2000)
Differences in incidence of reported asthma related to age in men and women. A retrospective analysis of the data of the European Respiratory Health Survey.American journal of respiratory and critical care medicine, 162 1
E Hamelmann, J Schwarze, K Takeda, A Oshiba, GL Larsen (1997)
Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography [see comments]Am J Respir Crit Care Med, 156
N. Pride, R. Ingram, T. Lim (1991)
Interaction between parenchyma and airways in chronic obstructive pulmonary disease and in asthma.The American review of respiratory disease, 143 6
(1997)
Definitions and clinical classification
A. Shedlovsky, J. McDonald, D. Symula, W. Dove (1993)
Mouse models of human phenylketonuria.Genetics, 134 4
S. Lum, A. Hoo, C. Dezateux, I. Goetz, A. Wade, L. DeRooy, K. Costeloe, J. Stocks (2001)
The association between birthweight, sex, and airway function in infants of nonsmoking mothers.American journal of respiratory and critical care medicine, 164 11
E. Hamelmann, J. Schwarze, K. Takeda, A. Oshiba, G. Larsen, C. Irvin, E. Gelfand (1997)
Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography.American journal of respiratory and critical care medicine, 156 3 Pt 1
R. Clifford, A. Pugsley, M. Radford, S. Holgate (1987)
Symptoms, atopy, and bronchial response to methacholine in parents with asthma and their children.Archives of Disease in Childhood, 62
L. Pinto, J. Takahashi (2001)
Functional identification of neural genes
S. Hoffjan, C. Ober (2002)
Present status on the genetic studies of asthma.Current opinion in immunology, 14 6
P. Ernst, H. Ghezzo, M. Becklake (2002)
Risk factors for bronchial hyperresponsiveness in late childhood and early adolescenceEuropean Respiratory Journal, 20
R. Hopp, A. Bewtra, G. Watt, N. Nair, R. Townley (1984)
Genetic analysis of allergic disease in twins.The Journal of allergy and clinical immunology, 73 2
N. Bahceciler, Ç. Arıkan, T. Akkoç, I. Barlan (2001)
Predictors for the severity of bronchial hyperreactivity in childhood asthma.American journal of respiratory and critical care medicine, 164 7
We mutagenized male BTBR mice with N-ethyl-N-nitrosourea and screened 1315 of their G3 offspring for airway hyperresponsiveness. A phenovariant G3 mouse with exaggerated methacholine bronchoconstrictor response was identified and his progeny bred in a nonspecific-pathogen-free (SPF) facility where sentinels tested positive for minute virus of mice and mouse parvovirus and where softwood bedding was used. The mutant phenotype was inherited through G11 as a single autosomal semidominant mutation with marked gender restriction, with males exhibiting almost full penetrance and very few females phenotypically abnormal. Between G11 and G12, facility infection eradication was undertaken and bedding was changed to hardwood. We could no longer detect airway hyperresponsiveness in more than 37 G12 offspring of 26 hyperresponsive G11 males. Also, we could not identify the mutant phenotype among offspring of hyperresponsive G8–G10 sires rederived into an SPF facility despite 21 attempts. These two observations suggest that both genetic and environmental factors were needed for phenotype expression. We suspect that rederivation into an SPF facility or altered exposure to pathogens or other unidentified substances modified environmental interactions with the mutant allele, and so resulted in disappearance of the hyperresponsive phenotype. Our experience suggests that future searches for genes that confer susceptibility for airway hyperresponsiveness might not be able to identify some genes that confer susceptibility if the searches are performed in SPF facilities. Experimenters are advised to arrange for multigeneration constancy of mouse care in order to clone mutant genes. Indeed, we were not able to map the mutation before losing the phenotype.
Mammalian Genome – Springer Journals
Published: Jan 1, 2008
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