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Gefitinib

Gefitinib Reactions 1680, p150 - 2 Dec 2017 Bleeding during surgery: case report A 60-year-old woman developed fatal bleeding during treatment with gefitinib. The woman, who had been diagnosed with stage IIIA nonsmall cell lung carcinoma 8 years previously, was hospitalised with complaints of chest pain. She had been receiving chemotherapy with gefitinib [route and dosage not stated] along with aspirin, metoprolol, iron and vitamin- B12-analogues [vitamin B12]. After admission, her chest radiograph revealed left perihilar parenchymal scars, surgical clips and postoperative changes in the chest. Subsequently, she underwent exercise nuclear stress test which revealed indeterminate ECG changes and a small artifactual anteroseptal wall defect. After undergoing the stress test, she complained of retrosternal chest pain. Her serum troponin level was noted to be increased. Subsequently, coronary angiography revealed 90% stenosis of the left main coronary artery ostium, which was described as radiation induced coronary artery disease (RICAD). A coronary artery bypass graft/surgical revascularisation was planned. Overnight, she suffered with intense anginal chest pain without any elevation in cardiac enzymes. Therefore, the surgery was initiated. During the surgery, dense adhesions surrounding the heart were observed. She developed severe bleeding from the adhesions [duration of treatment to reaction onset not stated]. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Gefitinib

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Gefitinib

Abstract

Reactions 1680, p150 - 2 Dec 2017 Bleeding during surgery: case report A 60-year-old woman developed fatal bleeding during treatment with gefitinib. The woman, who had been diagnosed with stage IIIA nonsmall cell lung carcinoma 8 years previously, was hospitalised with complaints of chest pain. She had been receiving chemotherapy with gefitinib [route and dosage not stated] along with aspirin, metoprolol, iron and vitamin- B12-analogues [vitamin B12]. After admission, her chest radiograph...
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Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
DOI
10.1007/s40278-017-39081-3
Publisher site
See Article on Publisher Site

Abstract

Reactions 1680, p150 - 2 Dec 2017 Bleeding during surgery: case report A 60-year-old woman developed fatal bleeding during treatment with gefitinib. The woman, who had been diagnosed with stage IIIA nonsmall cell lung carcinoma 8 years previously, was hospitalised with complaints of chest pain. She had been receiving chemotherapy with gefitinib [route and dosage not stated] along with aspirin, metoprolol, iron and vitamin- B12-analogues [vitamin B12]. After admission, her chest radiograph revealed left perihilar parenchymal scars, surgical clips and postoperative changes in the chest. Subsequently, she underwent exercise nuclear stress test which revealed indeterminate ECG changes and a small artifactual anteroseptal wall defect. After undergoing the stress test, she complained of retrosternal chest pain. Her serum troponin level was noted to be increased. Subsequently, coronary angiography revealed 90% stenosis of the left main coronary artery ostium, which was described as radiation induced coronary artery disease (RICAD). A coronary artery bypass graft/surgical revascularisation was planned. Overnight, she suffered with intense anginal chest pain without any elevation in cardiac enzymes. Therefore, the surgery was initiated. During the surgery, dense adhesions surrounding the heart were observed. She developed severe bleeding from the adhesions [duration of treatment to reaction onset not stated].

Journal

Reactions Weekly – Springer Journals

Published: Dec 2, 2017

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