Langenbecks Arch Surg (2017) 402:901–910 DOI 10.1007/s00423-017-1601-x ORIGINAL ARTICLE Gastric bypass simultaneously improves adipose tissue function and insulin-dependent type 2 diabetes mellitus 1 2 1 1 Adrian T. Billeter & Spiros Vittas & Barbara Israel & Katharina M. Scheurlen & 2 2 2 1 Asa Hidmark & Thomas H. Fleming & Stefan Kopf & Markus W. Büchler & Beat P. Müller-Stich Received: 26 May 2017 /Accepted: 29 June 2017 /Published online: 9 July 2017 Springer-Verlag GmbH Germany 2017 Abstract an M2-type inflammation. Loss of BMI correlated with leptin Objective The underlying causes of type 2 diabetes (T2DM) levels (r =0.891, p < 0.0001), insulin resistance (r =0.527, remain poorly understood. Adipose tissue dysfunction with p = 0.003), and oxidative stress (r =0.592, p = 0.016). Leptin high leptin, inflammation, and increased oxidative stress correlated with improved insulin resistance (r = 0.449, may play a pivotal role in T2DM development in obese pa- p = 0.032) while reduced leptin showed a strong association tients. Little is known about the changes in the adipose tissue with improved oxidative stress (r = 0.809, p = 0.001). Lastly, after Roux-Y gastric bypass (RYGB) in non-severely obese reduced oxidative stress correlated strongly with improved
Langenbeck's Archives of Surgery – Springer Journals
Published: Jul 9, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera