Gastric bypass simultaneously improves adipose tissue function and insulin-dependent type 2 diabetes mellitus

Gastric bypass simultaneously improves adipose tissue function and insulin-dependent type 2... Langenbecks Arch Surg (2017) 402:901–910 DOI 10.1007/s00423-017-1601-x ORIGINAL ARTICLE Gastric bypass simultaneously improves adipose tissue function and insulin-dependent type 2 diabetes mellitus 1 2 1 1 Adrian T. Billeter & Spiros Vittas & Barbara Israel & Katharina M. Scheurlen & 2 2 2 1 Asa Hidmark & Thomas H. Fleming & Stefan Kopf & Markus W. Büchler & Beat P. Müller-Stich Received: 26 May 2017 /Accepted: 29 June 2017 /Published online: 9 July 2017 Springer-Verlag GmbH Germany 2017 Abstract an M2-type inflammation. Loss of BMI correlated with leptin Objective The underlying causes of type 2 diabetes (T2DM) levels (r =0.891, p < 0.0001), insulin resistance (r =0.527, remain poorly understood. Adipose tissue dysfunction with p = 0.003), and oxidative stress (r =0.592, p = 0.016). Leptin high leptin, inflammation, and increased oxidative stress correlated with improved insulin resistance (r = 0.449, may play a pivotal role in T2DM development in obese pa- p = 0.032) while reduced leptin showed a strong association tients. Little is known about the changes in the adipose tissue with improved oxidative stress (r = 0.809, p = 0.001). Lastly, after Roux-Y gastric bypass (RYGB) in non-severely obese reduced oxidative stress correlated strongly with improved http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Langenbeck's Archives of Surgery Springer Journals

Gastric bypass simultaneously improves adipose tissue function and insulin-dependent type 2 diabetes mellitus

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag GmbH Germany
Subject
Medicine & Public Health; General Surgery; Abdominal Surgery; Cardiac Surgery; Thoracic Surgery; Traumatic Surgery; Vascular Surgery
ISSN
1435-2443
eISSN
1435-2451
D.O.I.
10.1007/s00423-017-1601-x
Publisher site
See Article on Publisher Site

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