Reactions 1704, p171 - 2 Jun 2018 Worsening of thrombocytopenia and neutropenia: case report A male infant [age at the time of reaction onset not clearly stated] showed worsened persistent thrombocytopenia and neutropenia during treatment with ganciclovir for congenital cytomegalovirus infection. The male infant was born by normal vaginal delivery to a primigravida mother at 36 weeks of gestation. He was hydropic with a generalised petechial rash, jaundice and splenomegaly and was found to be profoundly hypoglycaemic. His blood tests results showed anaemia, thrombocytopenia, low levels of neutrophils and platelets, coagulopathy, deranged liver function and hypoalbuminaemia. On day 3 of the birth, the cytomegalovirus (CMV) titre result was found positive, and he started receiving treatment with IV ganciclovir [dosage not stated]. Further investigations revealed the underlying of neonatal haemochromatosis. He received double volume red cell exchange transfusion and IV immunoglobulin-G treatment. Seven weeks post-delivery, he showed abnormal but stabilised liver function tests, but he continued to show persistent neutropenia and thrombocytopenia, which was attributed to ganciclovir and underlying cytomegalovirus infection. The cytomegalovirus titres eventually decreased and eventually, he was discharged on valganciclovir treatment. Author comment: "He had persistent thrombocytopenia and neutropenia likely attributable to CMV infection and antiviral medication." Stewart E, et al. Red cell exchange transfusion for neonatal haemochromatosis accompanied by congenital cmv infection. British Journal of Haematology 181 (Suppl. 1): 151-152 abstr. BSH18-PO-190, Apr 2018. Available from: URL: http:// doi.org/10.1111/bjh.15226 [abstract] - United Kingdom 803323633 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704
Reactions Weekly – Springer Journals
Published: Jun 2, 2018
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