Gabapentin overdose and abuse

Gabapentin overdose and abuse Reactions 1680, p148 - 2 Dec 2017 O S Hyponatraemia: case report A 51-year-old man developed hyponatraemia following gabapentin overdose, additionally he was also abusing gabapentin prescribed for restless leg syndrome (off label use) [route and time to reaction onset not stated]. The man was transferred to the behavioural care pavilion for depression and anxiety. Before presentation, he was admitted to ICU for gabapentin overdose (78g) over past 48 hours. He was treated for hyponatraemia associated with gabapentin overdose, which he was prescribed for restless leg syndrome. Records provided by transferring facility stated that he had been to hospital 32 times in past 8 months and had 10 hospitalisations, out of which eight were related to overdose both intentional and unintentional. Prior to admission he was treated with various medications including gabapentin. He denied current use or abuse of opiods, alcohol or benzodiazepine, but urine drug screen was positive for opioids. It was discovered that in last several months, three different doctors had prescribed gabapentin to him and he transferred prescriptions between various pharmacies. He also had a history of seizures related to overdose and withdrawal of gabapentin. Prior to presentation to emergency department, he reported of seizure activity and vomiting. During inpatient treatment, he denied for cravings for any substance including gabapentin, except tobacco. During hospitalisation, the man was treated for anxiety and depression and was discharged after 6 days. Additionally, his psychiatric medications were adjusted and he was started on naltrexone. Gabapentin treatment was stopped and for restless leg syndrome, he was started on ropinirole. Author comment: "The patient was treated for hyponatremia related to gabapentin overdose prior to transfer." "The following case reports a patient with compulsive gabapentin abuse". Banker K, et al. Compulsive gabapentin abuse despite lack of desirable effects: A case report. Journal of Substance Use 22: 661-663, No. 6, 2 Nov 2017. Available from: URL: http://doi.org/10.1080/14659891.2016.1271042 - USA 803285187 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Gabapentin overdose and abuse

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-017-39079-4
Publisher site
See Article on Publisher Site

Abstract

Reactions 1680, p148 - 2 Dec 2017 O S Hyponatraemia: case report A 51-year-old man developed hyponatraemia following gabapentin overdose, additionally he was also abusing gabapentin prescribed for restless leg syndrome (off label use) [route and time to reaction onset not stated]. The man was transferred to the behavioural care pavilion for depression and anxiety. Before presentation, he was admitted to ICU for gabapentin overdose (78g) over past 48 hours. He was treated for hyponatraemia associated with gabapentin overdose, which he was prescribed for restless leg syndrome. Records provided by transferring facility stated that he had been to hospital 32 times in past 8 months and had 10 hospitalisations, out of which eight were related to overdose both intentional and unintentional. Prior to admission he was treated with various medications including gabapentin. He denied current use or abuse of opiods, alcohol or benzodiazepine, but urine drug screen was positive for opioids. It was discovered that in last several months, three different doctors had prescribed gabapentin to him and he transferred prescriptions between various pharmacies. He also had a history of seizures related to overdose and withdrawal of gabapentin. Prior to presentation to emergency department, he reported of seizure activity and vomiting. During inpatient treatment, he denied for cravings for any substance including gabapentin, except tobacco. During hospitalisation, the man was treated for anxiety and depression and was discharged after 6 days. Additionally, his psychiatric medications were adjusted and he was started on naltrexone. Gabapentin treatment was stopped and for restless leg syndrome, he was started on ropinirole. Author comment: "The patient was treated for hyponatremia related to gabapentin overdose prior to transfer." "The following case reports a patient with compulsive gabapentin abuse". Banker K, et al. Compulsive gabapentin abuse despite lack of desirable effects: A case report. Journal of Substance Use 22: 661-663, No. 6, 2 Nov 2017. Available from: URL: http://doi.org/10.1080/14659891.2016.1271042 - USA 803285187 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680

Journal

Reactions WeeklySpringer Journals

Published: Dec 2, 2017

References

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