Digestive Diseases and Sciences (2018) 63:2165–2167 https://doi.org/10.1007/s10620-018-5116-2 EDITORIAL 1 1 Allen A. Lee · William L. Hasler Published online: 31 May 2018 © Springer Science+Business Media, LLC, part of Springer Nature 2018 Distressing symptoms such as post-prandial nausea, bloat- Grading Assessment Score (CPGAS). Nonetheless, several ing, a sense of fullness, and vomiting are associated with items require closer examination. First, these subjects almost the syndrome of gastroparesis, a condition associated with all had mild symptoms at baseline with an average Gastro- abnormal retention of food and fluid in the stomach. A sub - paresis Cardinal Symptom Index (GCSI) score of 2.1, even set of gastroparesis patients have “pyloropasm”, initially though they were labeled as “refractory gastroparesis” by described by Mearin et al.  as abnormally prolonged, the authors. It is unclear why the authors used the validated high-amplitude pyloric contractions in a 1986 study of 14 Patient Assessment of Gastrointestinal Disorders-Symptom of 24 diabetic patients with nausea and vomiting. Follow- Severity Index (PAGI-SYM) survey as their baseline ques- ing publication of this study, the contribution of the pylorus tionnaire and CPGAS as their primary therapeutic endpoint. to symptoms and gastric emptying delays in gastroparesis GCSI, a 9-item questionnaire contained within PAGI-SYM, has been the
Digestive Diseases and Sciences – Springer Journals
Published: May 31, 2018
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