Fuzzy Expert System based on a Novel Hybrid Stem Cell (HSC) Algorithm for Classification of Micro Array Data

Fuzzy Expert System based on a Novel Hybrid Stem Cell (HSC) Algorithm for Classification of Micro... In the growing scenario, microarray data is extensively used since it provides a more comprehensive understanding of genetic variants among diseases. As the gene expression samples have high dimensionality it becomes tedious to analyze the samples manually. Hence an automated system is needed to analyze these samples. The fuzzy expert system offers a clear classification when compared to the machine learning and statistical methodologies. In fuzzy classification, knowledge acquisition would be a major concern. Despite several existing approaches for knowledge acquisition much effort is necessary to enhance the learning process. This paper proposes an innovative Hybrid Stem Cell (HSC) algorithm that utilizes Ant Colony optimization and Stem Cell algorithm for designing fuzzy classification system to extract the informative rules to form the membership functions from the microarray dataset. The HSC algorithm uses a novel Adaptive Stem Cell Optimization (ASCO) to improve the points of membership function and Ant Colony Optimization to produce the near optimum rule set. In order to extract the most informative genes from the large microarray dataset a method called Mutual Information is used. The performance results of the proposed technique evaluated using the five microarray datasets are simulated. These results prove that the proposed Hybrid Stem Cell (HSC) algorithm produces a precise fuzzy system than the existing methodologies. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Medical Systems Springer Journals

Fuzzy Expert System based on a Novel Hybrid Stem Cell (HSC) Algorithm for Classification of Micro Array Data

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Publisher
Springer US
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Medicine & Public Health; Health Informatics; Health Informatics; Statistics for Life Sciences, Medicine, Health Sciences
ISSN
0148-5598
eISSN
1573-689X
D.O.I.
10.1007/s10916-018-0910-0
Publisher site
See Article on Publisher Site

Abstract

In the growing scenario, microarray data is extensively used since it provides a more comprehensive understanding of genetic variants among diseases. As the gene expression samples have high dimensionality it becomes tedious to analyze the samples manually. Hence an automated system is needed to analyze these samples. The fuzzy expert system offers a clear classification when compared to the machine learning and statistical methodologies. In fuzzy classification, knowledge acquisition would be a major concern. Despite several existing approaches for knowledge acquisition much effort is necessary to enhance the learning process. This paper proposes an innovative Hybrid Stem Cell (HSC) algorithm that utilizes Ant Colony optimization and Stem Cell algorithm for designing fuzzy classification system to extract the informative rules to form the membership functions from the microarray dataset. The HSC algorithm uses a novel Adaptive Stem Cell Optimization (ASCO) to improve the points of membership function and Ant Colony Optimization to produce the near optimum rule set. In order to extract the most informative genes from the large microarray dataset a method called Mutual Information is used. The performance results of the proposed technique evaluated using the five microarray datasets are simulated. These results prove that the proposed Hybrid Stem Cell (HSC) algorithm produces a precise fuzzy system than the existing methodologies.

Journal

Journal of Medical SystemsSpringer Journals

Published: Feb 21, 2018

References

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