Curr Pathobiol Rep (2017) 5:301–314 DOI 10.1007/s40139-017-0150-x APPLICATION OF STEM CELLS IN ENDODERM DERIVATIVES (K SI-TAYEB AND G SULLIVAN, SECTION EDITORS) Future Challenges in the Generation of Hepatocyte-Like Cells From Human Pluripotent Stem Cells 1,2 1 1,2 Richard Siller & Sebastian Greenhough & Santosh Mathapati & 3,4,5,6 1,2,7,8 Karim Si-Tayeb & Gareth J. Sullivan Published online: 31 July 2017 Springer Science+Business Media, LLC 2017 Abstract ease modeling and drug metabolism. To date, there has been Purpose of Review The purpose of this review is to provide an little investigation of this aspect of hepatic biology reported in updated perspective on directing human pluripotent stem cells the field. (hPSCs) to hepatocyte-like-cells (HLCs) and the associated challenges. Recent Findings Recent advances in the hepatocyte differen- Keywords Humanpluripotentstemcells Inducedpluripotent . . . . tiation field have largely been focused on increasing the re- stem cells Embryonic stem cells Endoderm Hepatocytes producibility and definition of culture systems to further their Hepatic differentiation translation to a clinical setting. There have been advances using new extracellular matrices such as human laminins, and recent work using small molecules to drive the differenti- Introduction ation process has dramatically reduced the cost of producing HLCs with equivalent phenotypes
Current Pathobiology Reports – Springer Journals
Published: Jul 31, 2017
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