Functions of piRNAs and the Piwi protein in Drosophila

Functions of piRNAs and the Piwi protein in Drosophila Short regulatory RNAs 25–35 nucleotides in length, along with RNA-binding proteins of the Piwi family, constitute an evolutionarily conserved system that functions mainly in eukaryotic gonads. The system can be regarded as a variation of the RNA interference mechanism, which is based on the recognition of target RNA as a result of complementary interactions with piRNAs. Different variants of this regulatory system function both in germline cells, including stem cells, and somatic cells of the niche, ensuring maintenance of the germline stem cells and their differentiation. One of the most important functions (but not the only one) of this system is the repression of transposons, which guarantees genome stability in germline cells. This review focuses on the works of the authors in the context of outstanding international achievements in the rapidly evolving research area, the biology of piRNA and the functions of the Piwi protein. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Functions of piRNAs and the Piwi protein in Drosophila

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Publisher
Pleiades Publishing
Copyright
Copyright © 2015 by Pleiades Publishing, Inc.
Subject
Biomedicine; Human Genetics; Animal Genetics and Genomics; Microbial Genetics and Genomics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1134/S1022795415040055
Publisher site
See Article on Publisher Site

Abstract

Short regulatory RNAs 25–35 nucleotides in length, along with RNA-binding proteins of the Piwi family, constitute an evolutionarily conserved system that functions mainly in eukaryotic gonads. The system can be regarded as a variation of the RNA interference mechanism, which is based on the recognition of target RNA as a result of complementary interactions with piRNAs. Different variants of this regulatory system function both in germline cells, including stem cells, and somatic cells of the niche, ensuring maintenance of the germline stem cells and their differentiation. One of the most important functions (but not the only one) of this system is the repression of transposons, which guarantees genome stability in germline cells. This review focuses on the works of the authors in the context of outstanding international achievements in the rapidly evolving research area, the biology of piRNA and the functions of the Piwi protein.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Apr 21, 2015

References

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