Functional group transformation from amines to aldehydes via IBX oxidation

Functional group transformation from amines to aldehydes via IBX oxidation IBX oxidation of secondary aryl amines has been applied towards their functional group transformation to aldehydes using a facile post-process with satisfactory yields. The oxidation of N-benzylmethylamine was used as a model substrate and suggested that the ratio of IBX oxidant to amine should be 2:1. Subsequently, several aryl amines were subjected to these standard conditions, which revealed that the oxidative activity depends on the electronic and steric structures of the substituent groups in the substrates. The oxidative selectivity to secondary amines was also discovered. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Chemical Papers Springer Journals

Functional group transformation from amines to aldehydes via IBX oxidation

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Publisher
Springer International Publishing
Copyright
Copyright © 2017 by Institute of Chemistry, Slovak Academy of Sciences
Subject
Chemistry; Chemistry/Food Science, general; Industrial Chemistry/Chemical Engineering; Biochemistry, general; Medicinal Chemistry; Materials Science, general; Biotechnology
ISSN
0366-6352
eISSN
1336-9075
D.O.I.
10.1007/s11696-017-0313-6
Publisher site
See Article on Publisher Site

Abstract

IBX oxidation of secondary aryl amines has been applied towards their functional group transformation to aldehydes using a facile post-process with satisfactory yields. The oxidation of N-benzylmethylamine was used as a model substrate and suggested that the ratio of IBX oxidant to amine should be 2:1. Subsequently, several aryl amines were subjected to these standard conditions, which revealed that the oxidative activity depends on the electronic and steric structures of the substituent groups in the substrates. The oxidative selectivity to secondary amines was also discovered.

Journal

Chemical PapersSpringer Journals

Published: Oct 10, 2017

References

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