Functional Expression of GFP-linked Human Heart Sodium Channel (hH1) and Subcellular Localization of the a Subunit in HEK293 Cells and Dog Cardiac Myocytes

Functional Expression of GFP-linked Human Heart Sodium Channel (hH1) and Subcellular Localization... J. Membrane Biol. 186, 1–12 (2002) DOI: 10.1007/s00232-001-0130-1 Functional Expression of GFP-linked Human Heart Sodium Channel (hH1) and Subcellular Localization of the a Subunit in HEK293 Cells and Dog Cardiac Myocytes 1 1 1 2 1 1,* 3 T. Zimmer, C. Biskup, S. Dugarmaa, F. Vogel, M. Steinbis, T. Bo¨ hle, Y.S. Wu, 3 1 R. Dumaine, K. Benndorf Friedrich Schiller University Jena, Institute of Physiology II, Teichgraben 8, 07740 Jena, Germany. Max Delbru¨ ck Centre for Molecular Medicine, Robert-Ro¨ ssle-Str. 10, 13125 Berlin, Germany. Masonic Medical Research Laboratory, Utica NY 13501, USA. Received: 15 May 2001/Revised: 29 September 2001 Abstract. Recent evidence suggests that biosynthesis limiting steps for sarcolemmal expression of Na of the human heart Na channel (hH1) protein is channels. rapidly modulated by sympathetic interventions. However, data regarding the intracellular processing Key words: ER proliferation — Golgi apparatus — of hH1 in vivo are lacking. In this study we sought to Heart ventricle — Immunoelectron microscopy — establish a model that would allow us to study the Voltage-gated Na channel subcellular localization of hH1 protein. Such a model could eventually help us to better understand the trafficking of hH1 in vivo and its potential role in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Membrane Biology Springer Journals

Functional Expression of GFP-linked Human Heart Sodium Channel (hH1) and Subcellular Localization of the a Subunit in HEK293 Cells and Dog Cardiac Myocytes

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Publisher
Springer-Verlag
Copyright
Copyright © 2002 by Springer-Verlag New York Inc.
Subject
Life Sciences; Biochemistry, general; Human Physiology
ISSN
0022-2631
eISSN
1432-1424
D.O.I.
10.1007/s00232-001-0130-1
Publisher site
See Article on Publisher Site

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