J. Membrane Biol. 186, 1–12 (2002) DOI: 10.1007/s00232-001-0130-1 Functional Expression of GFP-linked Human Heart Sodium Channel (hH1) and Subcellular Localization of the a Subunit in HEK293 Cells and Dog Cardiac Myocytes 1 1 1 2 1 1,* 3 T. Zimmer, C. Biskup, S. Dugarmaa, F. Vogel, M. Steinbis, T. Bo¨ hle, Y.S. Wu, 3 1 R. Dumaine, K. Benndorf Friedrich Schiller University Jena, Institute of Physiology II, Teichgraben 8, 07740 Jena, Germany. Max Delbru¨ ck Centre for Molecular Medicine, Robert-Ro¨ ssle-Str. 10, 13125 Berlin, Germany. Masonic Medical Research Laboratory, Utica NY 13501, USA. Received: 15 May 2001/Revised: 29 September 2001 Abstract. Recent evidence suggests that biosynthesis limiting steps for sarcolemmal expression of Na of the human heart Na channel (hH1) protein is channels. rapidly modulated by sympathetic interventions. However, data regarding the intracellular processing Key words: ER proliferation — Golgi apparatus — of hH1 in vivo are lacking. In this study we sought to Heart ventricle — Immunoelectron microscopy — establish a model that would allow us to study the Voltage-gated Na channel subcellular localization of hH1 protein. Such a model could eventually help us to better understand the traﬃcking of hH1 in vivo and its potential role in
The Journal of Membrane Biology – Springer Journals
Published: Mar 1, 2002
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