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M. Serrano, G. Hannon, D. Beach (1993)
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4Nature, 366
M. Vijver, Yudong He, L. Veer, H. Dai, A. Hart, D. Voskuil, G. Schreiber, J. Peterse, C. Roberts, M. Marton, M. Parrish, D. Atsma, A. Witteveen, A. Glas, L. Delahaye, Tony Velde, H. Bartelink, S. Rodenhuis, E. Rutgers, S. Friend, René Bernards (2002)
A gene-expression signature as a predictor of survival in breast cancer.The New England journal of medicine, 347 25
J. Rathjen, P. Rathjen (2001)
Mouse ES cells: experimental exploitation of pluripotent differentiation potential.Current opinion in genetics & development, 11 5
J. Schimenti, B. Libby, R. Bergstrom, L. Wilson, D. Naf, L. Tarantino, A. Alavizadeh, A. Lengeling, M. Bucan (2000)
Interdigitated deletion complexes on mouse chromosome 5 induced by irradiation of embryonic stem cells.Genome research, 10 7
E. Rinchik, Donald Carpenter (1999)
N-ethyl-N-nitrosourea mutagenesis of a 6- to 11-cM subregion of the Fah-Hbb interval of mouse chromosome 7: Completed testing of 4557 gametes and deletion mapping and complementation analysis of 31 mutations.Genetics, 152 1
K. Tsukamoto, K. Hirano, K. Tsujii, C. Ikegami, Zhongyang Zhang, Yoshiharu Nishida, T. Ohama, F. Matsuura, S. Yamashita, Y. Matsuzawa (2001)
ATP-binding cassette transporter-1 induces rearrangement of actin cytoskeletons possibly through Cdc42/N-WASP.Biochemical and biophysical research communications, 287 3
K. Mitchell, Kathleen Pinson, O. Kelly, J. Brennan, Joel Zupicich, P. Scherz, P. Leighton, L. Goodrich, Xiaowei Lu, B. Avery, P. Tate, Kariena Dill, Edivinia Pangilinan, Paul Wakenight, M. Tessier-Lavigne, W. Skarnes (2001)
Functional analysis of secreted and transmembrane proteins critical to mouse developmentNature Genetics, 28
E. Neufeld, A. Remaley, S. Demosky, J. Stonik, A. Cooney, M. Comly, N. Dwyer, Mei-kui Zhang, J. Blanchette-Mackie, S. Santamarina-Fojo, H. Brewer (2001)
Cellular Localization and Trafficking of the Human ABCA1 Transporter* 210The Journal of Biological Chemistry, 276
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler (2000)
Gene ontology: tool for the unification of biology. The Gene Ontology Consortium.Nat Genet, 25
K. Hirano, F. Matsuura, K. Tsukamoto, Zhongyang Zhang, A. Matsuyama, K. Takaishi, R. Komuro, T. Suehiro, S. Yamashita, Y. Takai, Y. Matsuzawa (2000)
Decreased expression of a member of the Rho GTPase family, Cdc42Hs, in cells from Tangier disease – the small G protein may play a role in cholesterol effluxFEBS Letters, 484
T. Burdon, Austin Smith, P. Savatier (2002)
Signalling, cell cycle and pluripotency in embryonic stem cells.Trends in cell biology, 12 9
V. Bode (1984)
Ethylnitrosourea mutagenesis and the isolation of mutant alleles for specific genes located in the T region of mouse chromosome 17.Genetics, 108 2
B. Chauhan, N. Reed, Weijia Zhang, M. Duncan, M. Kilimann, A. Cvekl (2002)
Identification of Genes Downstream of Pax6 in the Mouse Lens Using cDNA Microarrays* 210The Journal of Biological Chemistry, 277
Y. Hamon, C. Broccardo, O. Chambenoit, M. Luciani, F. Toti, Stephane Chaslin, J. Freyssinet, P. Devaux, J. Mcneish, D. Marguet, G. Chimini (2000)
ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine.Nature Cell Biology, 2
R. Munroe, R. Bergstrom, Q. Zheng, B. Libby, Richard Smith, S. John, K. Schimenti, Victoria Browning, J. Schimenti (2000)
Mouse mutants from chemically mutagenized embryonic stem cellsNature Genetics, 24
M. Eisen, P. Spellman, P. Brown, D. Botstein (1998)
Cluster analysis and display of genome-wide expression patterns.Proceedings of the National Academy of Sciences of the United States of America, 95 25
T. Tsutsui, B. Hesabi, D. Moons, P. Pandolfi, Kimberly Hansel, A. Koff, H. Kiyokawa (1999)
Targeted Disruption of CDK4 Delays Cell Cycle Entry with Enhanced p27Kip1 ActivityMolecular and Cellular Biology, 19
B. Zambrowicz, G. Friedrich, Eric Buxton, S. Lilleberg, C. Person, A. Sands (1998)
Disruption and sequence identification of 2,000 genes in mouse embryonic stem cellsNature, 392
M. Kanzaki, J. Pessin (2002)
Caveolin-associated Filamentous Actin (Cav-actin) Defines a Novel F-actin Structure in Adipocytes*The Journal of Biological Chemistry, 277
R. Gitan, Huidong Shi, Chuan‐Mu Chen, P. Yan, T. Huang (2002)
Methylation-specific oligonucleotide microarray: a new potential for high-throughput methylation analysis.Genome research, 12 1
M. Ramalho-Santos, Soonsang Yoon, Y. Matsuzaki, R. Mulligan, D. Melton (2002)
"Stemness": Transcriptional Profiling of Embryonic and Adult Stem CellsScience, 298
M. Ashburner, C. Ball, J. Blake, D. Botstein, Heather Butler, J. Cherry, A. Davis, K. Dolinski, S. Dwight, J. Eppig, M. Harris, D. Hill, L. Issel-Tarver, A. Kasarskis, S. Lewis, J. Matese, J. Richardson, M. Ringwald, G. Rubin, G. Sherlock (2000)
Gene Ontology: tool for the unification of biologyNature Genetics, 25
S. Hitotsumachi, D. Carpenter, W. Russell (1985)
Dose-repetition increases the mutagenic effectiveness of N-ethyl-N-nitrosourea in mouse spermatogonia.Proceedings of the National Academy of Sciences of the United States of America, 82 19
C. Buechler, S. Bared, C. Aslanidis, M. Ritter, W. Drobnik, G. Schmitz (2002)
Molecular and Functional Interaction of the ATP-binding Cassette Transporter A1 with Fas-associated Death Domain Protein*The Journal of Biological Chemistry, 277
Xiaohui Zha, J. Genest, R. McPherson (2001)
Endocytosis Is Enhanced in Tangier FibroblastsThe Journal of Biological Chemistry, 276
W. Skarnes (2000)
Gene trapping methods for the identification and functional analysis of cell surface proteins in mice.Methods in enzymology, 328
M. Angelis, H. Flaswinkel, H. Fuchs, B. Rathkolb, D. Soewarto, S. Marschall, S. Heffner, W. Pargent, K. Wuensch, M. Jung, A. Reis, T. Richter, F. Alessandrini, T. Jakob, Edith Fuchs, H. Kolb, E. Kremmer, Karlheinz Schaeble, Boris Rollinski, A. Roscher, C. Peters, T. Meitinger, T. Strom, T. Steckler, F. Holsboer, T. Klopstock, F. Gekeler, C. Schindewolf, Thomas Jung, K. Avraham, H. Behrendt, J. Ring, A. Zimmer, K. Schughart, K. Pfeffer, E. Wolf, R. Balling (2000)
Genome-wide, large-scale production of mutant mice by ENU mutagenesisNature Genetics, 25
C. Buechler, A. Boettcher, S. Bared, Mario Probst, G. Schmitz (2002)
The carboxyterminus of the ATP-binding cassette transporter A1 interacts with a beta2-syntrophin/utrophin complex.Biochemical and biophysical research communications, 293 2
William Stanford, J. Cohn, S. Cordes (2001)
Gene-trap mutagenesis: past, present and beyondNature Reviews Genetics, 2
Tetsuya Tanaka, T. Kunath, W. Kimber, S. Jaradat, C. Stagg, M. Usuda, T. Yokota, H. Niwa, J. Rossant, M. Ko (2002)
Gene expression profiling of embryo-derived stem cells reveals candidate genes associated with pluripotency and lineage specificity.Genome research, 12 12
S. Clee, J. Kastelein, M. Dam, M. Marcil, K. Roomp, Karin Zwarts, J. Collins, R. Roelants, N. Tamasawa, T. Štulc, T. Suda, R. Češka, B. Boucher, C. Rondeau, C. DeSouich, A. Brooks-Wilson, H. Molhuizen, Jiri Frohlich, J. Genest, M. Hayden (2000)
Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes.The Journal of clinical investigation, 106 10
W. Russell, E. Kelly, P. Hunsicker, J. Bangham, S. Maddux, E. Phipps (1979)
Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse.Proceedings of the National Academy of Sciences of the United States of America, 76 11
J. Mcneish, R. Aiello, D. Guyot, T. Turi, C. Gabel, C. Aldinger, K. Hoppe, M. Roach, L. Royer, Jeffery Wet, C. Broccardo, G. Chimini, O. Francone (2000)
High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1.Proceedings of the National Academy of Sciences of the United States of America, 97 8
Todd Golub, Todd Golub, D. Slonim, Pablo Tamayo, Christine Huard, Michelle Gaasenbeek, J. Mesirov, Hilary Coller, M. Loh, James Downing, Michael Caligiuri, C. Bloomfield, Eric Lander (1999)
Molecular classification of cancer: class discovery and class prediction by gene expression monitoring.Science, 286 5439
Raymond Cho, Mingxia Huang, M. Campbell, Helin Dong, L. Steinmetz, L. Sapinoso, G. Hampton, S. Elledge, Ronald Davis, D. Lockhart (2001)
Transcriptional regulation and function during the human cell cycleNature Genetics, 27
J. Nadeau (2000)
Muta-genetics or muta-genomics: the feasibility of large-scale mutagenesis and phenotyping programsMammalian Genome, 11
H.Steven Zhang, M. Gavin, A. Dahiya, A. Postigo, Duanduan Ma, Robin Luo, J. Harbour, D. Dean (2000)
Exit from G1 and S Phase of the Cell Cycle Is Regulated by Repressor Complexes Containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNFCell, 101
M. Wiles, F. Vauti, J. Otte, E. Füchtbauer, Patricia Ruiz, A. Füchtbauer, H. Arnold, H. Lehrach, Thomas Metz, H. Melchner, W. Wurst (2000)
Establishment of a gene-trap sequence tag library to generate mutant mice from embryonic stem cellsNature Genetics, 24
C. Friddle, T. Koga, E. Rubin, J. Bristow (2000)
Expression profiling reveals distinct sets of genes altered during induction and regression of cardiac hypertrophy.Proceedings of the National Academy of Sciences of the United States of America, 97 12
X Zha, J Jr Genest, R McPherson (2001)
Endocytosis is enhanced in Tangier fibroblasts: possible role of ATP-binding cassette protein A1 in endosomal vesicular transport.J Biol Chem, 276
Yijing Chen, J. Schimenti, T. Magnuson (2000)
Toward the yeastification of mouse genetics: chemical mutagenesis of embryonic stem cellsMammalian Genome, 11
J. Oram, Richard Lawn (2001)
ABCA1. The gatekeeper for eliminating excess tissue cholesterol.Journal of lipid research, 42 8
S. Rane, P. Dubus, R. Mettus, E. Galbreath, G. Boden, E. Reddy, M. Barbacid (1999)
Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasiaNature Genetics, 22
P. Nolan, J. Peters, M. Strivens, D. Rogers, J. Hagan, N. Spurr, I. Gray, L. Vizor, D. Brooker, E. Whitehill, R. Washbourne, Tertius Hough, Simon Greenaway, M. Hewitt, Xinhong Liu, Stefan McCormack, Karen Pickford, R. Selley, C. Wells, Z. Tymowska‐Lalanne, P. Roby, P. Glenister, Claire Thornton, C. Thaung, Julie-Anne Stevenson, R. Arkell, P. Mburu, R. Hardisty, A. Kiernan, A. Erven, K. Steel, S. Voegeling, J. Guénet, C. Nickols, R. Sadri, M. Naase, A. Isaacs, K. Davies, M. Browne, E. Fisher, Joanne Martin, S. Rastan, Steve Brown, J. Hunter (2000)
A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouseNature Genetics, 25
D. Stryke, M. Kawamoto, Conrad Huang, S. Johns, Leslie King, Courtney Harper, E. Meng, Roy Lee, A. Yee, L. L'Italien, P. Chuang, S. Young, W. Skarnes, P. Babbitt, T. Ferrin (2003)
BayGenomics: a resource of insertional mutations in mouse embryonic stem cellsNucleic acids research, 31 1
Yijing Chen, D. Yee, K. Dains, A. Chatterjee, J. Cavalcoli, Elizabeth Schneider, Jinsop Om, R. Woychik, T. Magnuson (2000)
Genotype-based screen for ENU-induced mutations in mouse embryonic stem cellsNature Genetics, 24
Expression profiling offers a potential high-throughput phenotype screen for mutant mouse embryonic stem (ES) cells. We have assessed the ability of expression arrays to distinguish among heterozygous mutant ES cell lines and to accurately reflect the normal function of the mutated genes. Two ES cell lines hemizygous for overlapping regions of mouse Chromosome (Chr) 5 differed substantially from the wildtype parental line and from each other. Expression differences included frequent downregulation of hemizygous genes and downstream effects on genes mapping to other chromosomes. Some genes were affected similarly in each deletion line, consistent with the overlap of the deletions. To determine whether such downstream effects reveal pathways impacted by a mutation, we examined ES cell lines heterozygous for mutations in either of two well-characterized genes. A heterozygous mutation in the gene encoding the cell cycle regulator, cyclin D kinase 4 (Cdk4), affected expression of many genes involved in cell growth and proliferation. A heterozygous mutation in the ATP binding cassette transporter family A, member 1 (Abca1) gene, altered genes associated with lipid homeostasis, the cytoskeleton, and vesicle trafficking. Heterozygous Abca1 mutation had similar effects in liver, indicating that ES cell expression profile reflects changes in fundamental processes relevant to mutant gene function in multiple cell types.
Mammalian Genome – Springer Journals
Published: Jan 1, 2002
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