J. Membrane Biol. 193, 67 78 (2003) The Journal of DOI: 10.1007/s00232-002-2001-9 Membrane Biology 9 Springer-Verlag New York Inc. 2003 Topical Review R. Warth l, J. Barhanin 2 Iphysiologisches lnstitut, Winterthurerstr. 190, 8057 ZUrich, Switzerland 2Institut de Pharmacologie du CNRS, 660 route de Lucioles, 06560 Valbonne Sophia-Antipolis, France Received: I I September 2002 Introduction two, four or six transmembrane domains and have in common a pore-forming loop that is part of the Potassium channels play an important role for reab- K +-selective filter . Additional regulatory sorptive and secretory pathways in the gastro-intes- subunits and hetero-multimerization are important tinal tract. Over the last years molecular identification for membrane targeting, pharmacology, and func- and functional characterization of K + channels led to tional properties [1, 2, 5, 103, 114, 116, 140]. Very a better understanding of physiology and disease of recently, fascinating structural data shed light on intestinal transport. In gastric parietal cells KCNJ10 the molecular principles of K + channel structure (Kir4.1) and heteromeric KCNE2/KCNQI (MirP1/ and function [58, 59]. Helpful overviews on the KvLQT1), K + channels co-localize with the acid- molecular diversity and nomenclature of the about producing H+/K + ATPase in the luminal membrane 85 different
The Journal of Membrane Biology – Springer Journals
Published: Mar 25, 2002
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