Full genomic analysis of a human group A rotavirus G9P(6) strain from Eastern India provides evidence for porcine-to-human interspecies transmission

Full genomic analysis of a human group A rotavirus G9P(6) strain from Eastern India provides... Deduced amino acid sequence and phylogenetic analyses of a group A rotavirus G9P(6) strain (designated as mcs/13-07), detected from a 3-year-old child in Eastern India, revealed a VP8* closely related to porcine P(6) strains (P(6) sublineage 1D), and the VP7 clustered with G9 lineage-III strains. To our knowledge, this is the first report of human P(6) strain clustering in sublineage Id. Thus, to further characterize the evolutionary diversity of strain mcs/13-07, all gene segments were analyzed. VP6 and NSP4 exhibited genetic relatedness to Wa-like human subgroup II strains, while VP1-3, NSP1-3 and NSP5 were closely related to porcine strains. Based on the new classification system of rotaviruses, mcs/13-07 revealed a G9–P(6)–I1–R1–C1–M1–A8–N1–T1–E1–H1 genotype with close similarity to human Wa-like and porcine Gottfried strains. Therefore, considering the porcine-like or porcine origin of multiple gene segments, it might be tempting to assume that strain mcs/13-07 represents a rare instance of whole-virus transmission from pig to human, after which the virus evolved with time. Alternatively, it is possible that strain mcs/13-07 resulted from multiple reassortment events involving human subgroup II and porcine P(6) strains. Nevertheless, detection of strain mcs/13-07 provides further evidence for complex interspecies transmission events, which are frequent in developing countries. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Full genomic analysis of a human group A rotavirus G9P(6) strain from Eastern India provides evidence for porcine-to-human interspecies transmission

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Publisher
Springer Journals
Copyright
Copyright © 2009 by Springer-Verlag
Subject
Biomedicine; Infectious Diseases; Medical Microbiology ; Virology
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-009-0363-3
Publisher site
See Article on Publisher Site

Abstract

Deduced amino acid sequence and phylogenetic analyses of a group A rotavirus G9P(6) strain (designated as mcs/13-07), detected from a 3-year-old child in Eastern India, revealed a VP8* closely related to porcine P(6) strains (P(6) sublineage 1D), and the VP7 clustered with G9 lineage-III strains. To our knowledge, this is the first report of human P(6) strain clustering in sublineage Id. Thus, to further characterize the evolutionary diversity of strain mcs/13-07, all gene segments were analyzed. VP6 and NSP4 exhibited genetic relatedness to Wa-like human subgroup II strains, while VP1-3, NSP1-3 and NSP5 were closely related to porcine strains. Based on the new classification system of rotaviruses, mcs/13-07 revealed a G9–P(6)–I1–R1–C1–M1–A8–N1–T1–E1–H1 genotype with close similarity to human Wa-like and porcine Gottfried strains. Therefore, considering the porcine-like or porcine origin of multiple gene segments, it might be tempting to assume that strain mcs/13-07 represents a rare instance of whole-virus transmission from pig to human, after which the virus evolved with time. Alternatively, it is possible that strain mcs/13-07 resulted from multiple reassortment events involving human subgroup II and porcine P(6) strains. Nevertheless, detection of strain mcs/13-07 provides further evidence for complex interspecies transmission events, which are frequent in developing countries.

Journal

Archives of VirologySpringer Journals

Published: May 1, 2009

References

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