Arch Virol (2009) 154:127–132 DOI 10.1007/s00705-008-0270-z BRIEF REPORT Full genome sequence of three isolates of hepatitis C virus subtype 4b from Portugal Diana Koletzki Æ Ste ´phanie Dumont Æ Hans Vermeiren Æ Paula Peixe Æ Jaime Nina Æ Ricardo J. Camacho Æ Lieven J. Stuyver Received: 25 August 2008 / Accepted: 9 November 2008 / Published online: 3 December 2008 Springer-Verlag 2008 Hepatitis C virus (HCV) genotype 4 has been previously Since the discovery of the hepatitis C virus (HCV) by shown to be prevalent in central Africa, the Middle East Choo et al. , a huge number of HCV strains have been and, more recently, with increasing numbers in western and characterized worldwide. To date, 6 major genotypes have southern Europe. In this study, the complete genomes of been identiﬁed and classiﬁed based on a consensus three different isolates from Portugal (P212, P245 and nomenclature . Each genotype differs from the others P026) were sequenced. The open reading frame of these by 30–35% on nucleotide level and may be further divided strains has a total of 9,036, 9,036 and 9,033 nt, respec- into several subtypes with sequence diversity typically tively. Phylogenetic analysis of the complete genome between 20
Archives of Virology – Springer Journals
Published: Jan 1, 2009
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