Fruit juice of Citrus limon as a biodegradable and reusable catalyst for facile, eco-friendly and green synthesis of 3,4-disubstituted isoxazol-5(4H)-ones and dihydropyrano[2,3-c]-pyrazole derivatives

Fruit juice of Citrus limon as a biodegradable and reusable catalyst for facile, eco-friendly and... Keywords Isoxazole-5(4H)-ones  Pyrano[2,3-c]-pyrazole  Lemon juice One-pot  Multi-component reaction  Homogeneous catalysis  Green synthesis Introduction Recently, multi-component reactions (MCRs) have received much attention in the field of synthetic organic chemistry as well as medicinal chemistry, because the strategies of MCR offer significant advantages over conventional synthetic methodologies [1]. Therefore, planning reactions that achieve multi-bond formation in one operation is becoming one of the leading challenges in the field of green organic synthesis [2]. The approach of MCRs delivers numbers of advantages over conventional transformations, such as shorter reaction times, higher product yields, lower costs, an easy work-up process, and environmental being [3]. Isoxazole scaffolds are important class of heterocyclic compounds, and they are predominant in nature and display a wide range of biological and pharmaceutical activities such as b-adrenergic receptor antagonists [4], immunosuppressive [5], anti-inflammatory [6], antibacterial [7], HDAC inhibitors [8], antifungal (I) [9], antitumor [10], antioxidant [11], antiprotozoal [12], antiviral [13], anti-tubercular [14], anti-inflammatory [15], anti-HIV [16], analgesic [17], antibiotics [18, 19], and anti-androgens (II) [20, 21]. Furthermore, compound (III) (drazoxolon) [22] and compound (IV) [23], which possess an isoxazolone ring, have been investigated as a fungicide and an inhibitor of tumor necrosis factor-alpha (TNF-a), http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Fruit juice of Citrus limon as a biodegradable and reusable catalyst for facile, eco-friendly and green synthesis of 3,4-disubstituted isoxazol-5(4H)-ones and dihydropyrano[2,3-c]-pyrazole derivatives

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Publisher
Springer Netherlands
Copyright
Copyright © 2016 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-016-2553-4
Publisher site
See Article on Publisher Site

Abstract

Keywords Isoxazole-5(4H)-ones  Pyrano[2,3-c]-pyrazole  Lemon juice One-pot  Multi-component reaction  Homogeneous catalysis  Green synthesis Introduction Recently, multi-component reactions (MCRs) have received much attention in the field of synthetic organic chemistry as well as medicinal chemistry, because the strategies of MCR offer significant advantages over conventional synthetic methodologies [1]. Therefore, planning reactions that achieve multi-bond formation in one operation is becoming one of the leading challenges in the field of green organic synthesis [2]. The approach of MCRs delivers numbers of advantages over conventional transformations, such as shorter reaction times, higher product yields, lower costs, an easy work-up process, and environmental being [3]. Isoxazole scaffolds are important class of heterocyclic compounds, and they are predominant in nature and display a wide range of biological and pharmaceutical activities such as b-adrenergic receptor antagonists [4], immunosuppressive [5], anti-inflammatory [6], antibacterial [7], HDAC inhibitors [8], antifungal (I) [9], antitumor [10], antioxidant [11], antiprotozoal [12], antiviral [13], anti-tubercular [14], anti-inflammatory [15], anti-HIV [16], analgesic [17], antibiotics [18, 19], and anti-androgens (II) [20, 21]. Furthermore, compound (III) (drazoxolon) [22] and compound (IV) [23], which possess an isoxazolone ring, have been investigated as a fungicide and an inhibitor of tumor necrosis factor-alpha (TNF-a),

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Apr 22, 2016

References

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