Keywords Isoxazole-5(4H)-ones Pyrano[2,3-c]-pyrazole Lemon juice One-pot Multi-component reaction Homogeneous catalysis Green synthesis Introduction Recently, multi-component reactions (MCRs) have received much attention in the ﬁeld of synthetic organic chemistry as well as medicinal chemistry, because the strategies of MCR offer signiﬁcant advantages over conventional synthetic methodologies . Therefore, planning reactions that achieve multi-bond formation in one operation is becoming one of the leading challenges in the ﬁeld of green organic synthesis . The approach of MCRs delivers numbers of advantages over conventional transformations, such as shorter reaction times, higher product yields, lower costs, an easy work-up process, and environmental being . Isoxazole scaffolds are important class of heterocyclic compounds, and they are predominant in nature and display a wide range of biological and pharmaceutical activities such as b-adrenergic receptor antagonists , immunosuppressive , anti-inﬂammatory , antibacterial , HDAC inhibitors , antifungal (I) , antitumor , antioxidant , antiprotozoal , antiviral , anti-tubercular , anti-inﬂammatory , anti-HIV , analgesic , antibiotics [18, 19], and anti-androgens (II) [20, 21]. Furthermore, compound (III) (drazoxolon)  and compound (IV) , which possess an isoxazolone ring, have been investigated as a fungicide and an inhibitor of tumor necrosis factor-alpha (TNF-a),
Research on Chemical Intermediates – Springer Journals
Published: Apr 22, 2016
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