Mamm Genome (2007) 18:383–388 DOI 10.1007/s00335-007-9044-2 COMMENTARY Rudi Balling Received: 11 June 2007 / Accepted: 11 June 2007 / Published online: 1 August 2007 Springer Science+Business Media, LLC 2007 Introduction mechanical engineering then triggered the development and application of systems control theory, a key require- It will not be long before we have mutant alleles for every ment for the modeling and simulation of the dynamics of gene in the mouse genome. It also will not be long before technical systems. we can sequence an entire genome in a few hours and for A major challenge in biology is to model, simulate, and less than 1000 US$. But there is much more to come, and eventually predict the behavior of complex biological the speed with which these developments will take place systems. The identiﬁcation of the individual components will surprise you. Imagine following the fate of every that constitute a biological system, i.e., through the gen- single cell during the development of a mouse from fer- ome-wide transcriptome, proteome, and metabolome tilization to birth and even beyond. Imagine watching the analysis, will be required but will not be sufﬁcient to expression of a single molecule of any protein or
Mammalian Genome – Springer Journals
Published: Aug 1, 2007
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