From ENU mutagenesis to population genetics

From ENU mutagenesis to population genetics Mamm Genome (2008) 19:221–225 DOI 10.1007/s00335-008-9104-2 COMMENTARY N. Avrion Mitchison Æ Bryan Clarke Received: 16 January 2008 / Accepted: 17 February 2008 / Published online: 26 March 2008 Springer Science+Business Media, LLC 2008 Introduction Experimental mutagenesis potentially can provide information valuable for population genetics. A key pro- Current approaches to population genetics focus on evo- cedure in the new genomics is to compare a variable that is lutionary information extracted from genomics, where subject to natural selection with a control variable sup- large-scale sequencing is telling us much about the oper- posedly unaffected in this way, typically nonsynonymous ation of natural selection. Within this field an important compared with synonymous nucleotide substitution issue is the nature and evolution of genetic dominance. (although there is evidence of at least some selection on Historically, inheritance in natural populations was viewed synonymous mutations). This type of analysis has not yet in terms of dominant ‘‘wild-type’’ alleles, following the been applied to the population genetics of dominance discovery of the reserve of recessive alleles present as because of the lack of an appropriate neutral control. Our heterozygotes in wild Drosophila as revealed by inbreeding purpose here is to inquire how data from mutagenesis http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

From ENU mutagenesis to population genetics

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Publisher
Springer-Verlag
Copyright
Copyright © 2008 by Springer Science+Business Media, LLC
Subject
Life Sciences; Zoology ; Anatomy ; Cell Biology
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/s00335-008-9104-2
Publisher site
See Article on Publisher Site

Abstract

Mamm Genome (2008) 19:221–225 DOI 10.1007/s00335-008-9104-2 COMMENTARY N. Avrion Mitchison Æ Bryan Clarke Received: 16 January 2008 / Accepted: 17 February 2008 / Published online: 26 March 2008 Springer Science+Business Media, LLC 2008 Introduction Experimental mutagenesis potentially can provide information valuable for population genetics. A key pro- Current approaches to population genetics focus on evo- cedure in the new genomics is to compare a variable that is lutionary information extracted from genomics, where subject to natural selection with a control variable sup- large-scale sequencing is telling us much about the oper- posedly unaffected in this way, typically nonsynonymous ation of natural selection. Within this field an important compared with synonymous nucleotide substitution issue is the nature and evolution of genetic dominance. (although there is evidence of at least some selection on Historically, inheritance in natural populations was viewed synonymous mutations). This type of analysis has not yet in terms of dominant ‘‘wild-type’’ alleles, following the been applied to the population genetics of dominance discovery of the reserve of recessive alleles present as because of the lack of an appropriate neutral control. Our heterozygotes in wild Drosophila as revealed by inbreeding purpose here is to inquire how data from mutagenesis

Journal

Mammalian GenomeSpringer Journals

Published: Mar 26, 2008

References

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