Frequencies of the CCR2-64I and SDF1-3"A Alleles Associated with Progression of the HIV-1 Disease in Healthy Individuals from Moscow

Frequencies of the CCR2-64I and SDF1-3"A Alleles Associated with Progression of the HIV-1 Disease... The frequencies of two mutations associated with the development of clinical symptoms upon infection with human immunodeficiency virus type 1 (HIV-1) were determined in a cohort of individuals from Moscow. Allelic frequency of the first mutation, CC2-64I, causing the substitution of valine with isoleucine in the CCR2 chemokine receptor, was 0.1106 (95% confidence interval, 0.0714–0.1498). The frequency of the second mutation, the G to A substitution in the 3"-untranslated region of the stromal-derived factor 1 encoding gene, SDF1- 3"A, was 0.2125 (95% confidential interval, 0.1608–0.2642). Both values were slightly higher than those obtained earlier for Western European countries. This result can be explained by higher proportion of migrants from Asian regions, characterized by higher frequencies of these mutations, in the population of Moscow. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Frequencies of the CCR2-64I and SDF1-3"A Alleles Associated with Progression of the HIV-1 Disease in Healthy Individuals from Moscow

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Publisher
Kluwer Academic Publishers-Plenum Publishers
Copyright
Copyright © 2002 by MAIK “Nauka/Interperiodica”
Subject
Biomedicine; Human Genetics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1023/A:1014398430706
Publisher site
See Article on Publisher Site

Abstract

The frequencies of two mutations associated with the development of clinical symptoms upon infection with human immunodeficiency virus type 1 (HIV-1) were determined in a cohort of individuals from Moscow. Allelic frequency of the first mutation, CC2-64I, causing the substitution of valine with isoleucine in the CCR2 chemokine receptor, was 0.1106 (95% confidence interval, 0.0714–0.1498). The frequency of the second mutation, the G to A substitution in the 3"-untranslated region of the stromal-derived factor 1 encoding gene, SDF1- 3"A, was 0.2125 (95% confidential interval, 0.1608–0.2642). Both values were slightly higher than those obtained earlier for Western European countries. This result can be explained by higher proportion of migrants from Asian regions, characterized by higher frequencies of these mutations, in the population of Moscow.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Oct 13, 2004

References

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