Freeze-drying assisted sol–gel-derived silica-based particles embedding iron: synthesis and characterization

Freeze-drying assisted sol–gel-derived silica-based particles embedding iron: synthesis and... New silica-based particles embedding iron were synthesized following a freeze-drying-assisted sol–gel route. The samples were preliminary characterized in view of potential applications as theranostic magnetic resonance imaging (MRI) contrast agents and for hyperthermia treatment. The structural changes induced by iron addition were studied by X-ray diffraction, Fourier transform infrared and electron paramagnetic resonance spectroscopies. The addition of Fe2O3 impedes the SiO2 crystallization denoting that iron plays, in this case, the role of a glass network stabilizer. The composition on surface and nearby was analyzed by X-ray photoelectron spectroscopy and energy dispersive X-ray spectroscopy both before and after samples immersion in simulated body fluid. The results suggest the nominal composition with 5 mol% Fe2O3 added to 0.7SiO2∙0.3Na2O matrix of interest for further investigations as potential MRI contrast agent and hyperthermia vector. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Sol-Gel Science and Technology Springer Journals

Freeze-drying assisted sol–gel-derived silica-based particles embedding iron: synthesis and characterization

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Publisher
Springer US
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Materials Science; Ceramics, Glass, Composites, Natural Materials; Inorganic Chemistry; Optical and Electronic Materials; Nanotechnology
ISSN
0928-0707
eISSN
1573-4846
D.O.I.
10.1007/s10971-018-4702-2
Publisher site
See Article on Publisher Site

Abstract

New silica-based particles embedding iron were synthesized following a freeze-drying-assisted sol–gel route. The samples were preliminary characterized in view of potential applications as theranostic magnetic resonance imaging (MRI) contrast agents and for hyperthermia treatment. The structural changes induced by iron addition were studied by X-ray diffraction, Fourier transform infrared and electron paramagnetic resonance spectroscopies. The addition of Fe2O3 impedes the SiO2 crystallization denoting that iron plays, in this case, the role of a glass network stabilizer. The composition on surface and nearby was analyzed by X-ray photoelectron spectroscopy and energy dispersive X-ray spectroscopy both before and after samples immersion in simulated body fluid. The results suggest the nominal composition with 5 mol% Fe2O3 added to 0.7SiO2∙0.3Na2O matrix of interest for further investigations as potential MRI contrast agent and hyperthermia vector.

Journal

Journal of Sol-Gel Science and TechnologySpringer Journals

Published: Jun 4, 2018

References

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