Free radicals formed by addition of antimalaric artemisinin (Qinghaosu, QHS) to human serum: an ESR-spin trapping investigation

Free radicals formed by addition of antimalaric artemisinin (Qinghaosu, QHS) to human serum: an... The antimalaric drug artemisinin (QHS) is believed to operate through a mechanism initiated with the cleavage of its endoperoxidic bond induced by transition metal ions. An ESR investigation of the reaction of QHS with human serum in the presence of two spin trapping agents has led to the detection of spin adducts of carbon-centred radicals. Experiments carried out replacing the human serum with iron(II) salts led to the observation of the same spin adducts, thus supporting previous suggestions that alsoin vivo the drug operatesvia a radical-based mechanism. UV irradiation of QHS also led to the trapping of transient free radicals. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Free radicals formed by addition of antimalaric artemisinin (Qinghaosu, QHS) to human serum: an ESR-spin trapping investigation

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Publisher
Brill Academic Publishers
Copyright
Copyright © 2004 by 2004 VSP
Subject
Chemistry; Inorganic Chemistry; Physical Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1163/1568567041570366
Publisher site
See Article on Publisher Site

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