Free radical activity of mineral fibres containing adsorbed ferritin: Detection using supercoiled DNA

Free radical activity of mineral fibres containing adsorbed ferritin: Detection using supercoiled... Mammalian ferritin was found to adsorb strongly, from aqueous solutions, onto the amphibole group minerals amosite and crocidolite. The mineral fibres containing adsorbed ferritin were found to show high free-radical activity leading to radical damage to DNA, which was quantified by electrophoretic assays with the pCSI2 plasmid. The results are discussed in terms of possible implications in the pathogenicity of asbestos bodies which are formed in vivo after inhaling mineral fibres, and which often contain endogenous ferritin in their coatings. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Free radical activity of mineral fibres containing adsorbed ferritin: Detection using supercoiled DNA

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Publisher
Springer Netherlands
Copyright
Copyright © 1999 by Springer
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1163/156856799X00284
Publisher site
See Article on Publisher Site

Abstract

Mammalian ferritin was found to adsorb strongly, from aqueous solutions, onto the amphibole group minerals amosite and crocidolite. The mineral fibres containing adsorbed ferritin were found to show high free-radical activity leading to radical damage to DNA, which was quantified by electrophoretic assays with the pCSI2 plasmid. The results are discussed in terms of possible implications in the pathogenicity of asbestos bodies which are formed in vivo after inhaling mineral fibres, and which often contain endogenous ferritin in their coatings.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Apr 15, 2009

References

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