Dig Dis Sci (2018) 63:628–635 https://doi.org/10.1007/s10620-017-4815-4 ORIGINAL ARTICLE Fragments of e-Cadherin as Biomarkers of Non-erosive Reﬂux Disease 1,3 1,2 1,5 1,8 • • • • Biljana Jovov Craig C. Reed Nicholas J. Shaheen Amy Pruitt 1,6 1,7 1,4 1,7 • • • Kathleen Ferrell Geraldine S. Orlando Zorka Djukic Roy C. Orlando Received: 26 August 2017 / Accepted: 17 October 2017 / Published online: 25 October 2017 Springer Science+Business Media, LLC 2017 Abstract received dexlansoprazole 30 mg daily for 4 weeks, and Background Approximately, 20% of patients with heart- heartburn was assessed by daily diary entry. Post-treatment burn and normal endoscopic ﬁndings do not symptomati- blood samples were obtained for serum NTFs. A control cally improve on proton pump inhibitor (PPI) therapy group without GERD symptoms (n = 6) had biopsies for making diagnosis and treatment uncertain. A biomarker CTFs and a second control group (n = 20) blood serum for distinguishing PPI-responsive from PPI-refractory heart- serum NTFs. burn is desirable. Results Twenty-seven of 29 patients (93.1%) with endo- Aims We performed a pilot study assessing whether car- scopy-negative heartburn, but 0 of 6 controls, were positive boxy(C)-terminal fragments (CTFs) of e-cadherin in eso- for CTFs. All patients and
Digestive Diseases and Sciences – Springer Journals
Published: Oct 25, 2017
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