LETTER TO THE EDITOR Fractional ﬂow reserve as an indicator of coronary circulation with special reference to kidney function Xaplanteris et al reviewed physiological indicators via Disclosure catheterization to know the level of coronary circulation. There is no conﬂict of interest in this study. Among them, fractional ﬂow reserve (FFR) value has been used for evaluating severity of coronary stenosis. As there was no information on the relationship between Tomoyuki Kawada, MD, FFR and chronic kidney disease (CKD) in the article, I Department of Hygiene and Public Health, Nippon Medical School, 1-1-5 present some references. Sendagi, Bunkyo-Ku, Tokyo 113-8602, Tebaldietal evaluated the effect of CKD on FFR Japan; email@example.com. value in patients with intermediate coronary stenosis. CKD was deﬁned as creatinine clearance value B45 ml/min, and FFR positive was deﬁned as B0.80. References Adjusted hazard ratios (HRs) (95% conﬁdence inter- 1. Xaplanteris P, Barbato E, De Bruyne B. Catheter-based functional vals (CIs)) of diabetes and CKD for FFR positive were metrics of the coronary circulation. J Nucl Cardiol. 2016. doi: 1.07 (1.008-1.13) and 0.92 (0.87-0.97), respectively. 10.1007/s12350-016-0652-7. In contrast, Mohandas et al reported a positive 2. Tebaldi M, Biscaglia S, Fineschi M, Manari A, Menozzi M, Secco relationship between renal function and FFR. A GG, et al. Fractional ﬂow reserve evaluation and chronic kidney standardized way of FFR measurements is important, disease: analysis from a multicenter Italian registry (the FREAK Study). Catheter Cardiovasc Interv 2016;88:555-62. and inconsistent results on the relationship between 3. Mohandas R, Segal MS, Huo T, Handberg EM, Petersen JW, FFR and CKD would partly be explained by the pro- Johnson BD, et al. Renal function and coronary microvascular cedure of measurement. Anyway, CKD information in dysfunction in women with symptoms/signs of ischemia. PLoS One relation to FFR value should be conﬁrmed by further 2015;10:e0125374. study. doi:10.1007/s12350-017-0786-2 This Letter to the Editor is in response to a Review Article with doi: 10.1007/s12350-016-0652-7. J Nucl Cardiol 2017;24:1458. 1071-3581/$34.00 Copyright 2017 American Society of Nuclear Cardiology.
Journal of Nuclear Cardiology – Springer Journals
Published: Jan 26, 2017
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