Int Urol Nephrol (2017) 49:1637–1643 DOI 10.1007/s11255-017-1627-6 NEPHROLOGY - ORIGINAL PAPER Fosfomycin for the treatment of drug‑resistant urinary tract infections: potential of an old drug not explored fully 1 1 Vrushali Patwardhan · Sarman Singh Received: 18 January 2017 / Accepted: 19 May 2017 / Published online: 14 June 2017 © Springer Science+Business Media Dordrecht 2017 Abstract Gram-positive isolates [698/707 (96%)] and MRSA [61/69 Introduction Increased emergence of bacterial resistance (88.4%)] were susceptible to fosfomycin. and the limited options of novel antimicrobial agents have Conclusions Fosfomycin showed an excellent in vitro necessitated the reintroduction of some old antimicrobial activity against all urinary pathogens, including the Gram- agents. One such drug is fosfomycin, but its potential has positive or Gram-negative, ESBL and MBL producers. Fos- not been explored fully, especially in India. fomycin should be considered as a highly effective alterna- Aims and objectives To analyze the in vitro activity of fos- tive in treatment UTIs in both adults and pediatric patients. fomycin, against the urinary isolates and to compare it with in vitro activity of other orally administered antimicrobial Keywords Uropathogens · Fosfomycin · EMBL · ESBL agents. Materials and methods This was a prospective observa- tional study conducted
International Urology and Nephrology – Springer Journals
Published: Jun 14, 2017
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