In this research, a thermosensitive system with proper physiomechanical properties and prepared with biocompatible materials was used to increase mucoadhesion, to control drug delivery and to decrease the local irritation. Thus, Tsol–gel temperatures approximately between 26–27 and 37–38 °C were found. The solid dispersion increases the solubility and Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10971-018-4662-6) contains supplementary material, which is available to authorized users. * Marco Chaud Laboratory of Toxicological Research, University of Sorocaba, email@example.com Sorocaba, São Paulo 18023-000, Brazil Laboratory of Nanotechnology and Nanomedicine, University of Laboratory of Biomaterials and Nanotechnology, University of Tiradentes, Aracaju, Sergipe 49010-390, Brazil Sorocaba, Sorocaba, São Paulo 18023-000, Brazil Biotechnology Laboratory, S G B Amrãvati University, Laboratory of Biotechnology, University of Sorocaba, Amrãvati 444-602, India Sorocaba, São Paulo 18023-000, Brazil 1234567890();,: 1234567890();,: Journal of Sol-Gel Science and Technology (2018) 86:536–552 537 stability of curcumin. This formulation was designed for treatment of vaginal mucositis, HPV, bacterial infection and other vaginal diseases. ● ● ● ● Keywords Thermoresponsive hydrogel Polymeric blends Poloxamer 407 Vaginal controlled delivery system Curcumin Drug delivery Highlights Tsol–gel hydrogel was prepared with biocompatible materials for vaginal administration. The solid dispersion technique was used to improve the curcumin water
Journal of Sol-Gel Science and Technology – Springer Journals
Published: May 4, 2018
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