Formulation and evaluation of thermoresponsive polymeric blend as a vaginal controlled delivery system

Formulation and evaluation of thermoresponsive polymeric blend as a vaginal controlled delivery... In this research, a thermosensitive system with proper physiomechanical properties and prepared with biocompatible materials was used to increase mucoadhesion, to control drug delivery and to decrease the local irritation. Thus, Tsol–gel temperatures approximately between 26–27 and 37–38 °C were found. The solid dispersion increases the solubility and Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10971-018-4662-6) contains supplementary material, which is available to authorized users. * Marco Chaud Laboratory of Toxicological Research, University of Sorocaba, marco.chaud@prof.uniso.br Sorocaba, São Paulo 18023-000, Brazil Laboratory of Nanotechnology and Nanomedicine, University of Laboratory of Biomaterials and Nanotechnology, University of Tiradentes, Aracaju, Sergipe 49010-390, Brazil Sorocaba, Sorocaba, São Paulo 18023-000, Brazil Biotechnology Laboratory, S G B Amrãvati University, Laboratory of Biotechnology, University of Sorocaba, Amrãvati 444-602, India Sorocaba, São Paulo 18023-000, Brazil 1234567890();,: 1234567890();,: Journal of Sol-Gel Science and Technology (2018) 86:536–552 537 stability of curcumin. This formulation was designed for treatment of vaginal mucositis, HPV, bacterial infection and other vaginal diseases. ● ● ● ● Keywords Thermoresponsive hydrogel Polymeric blends Poloxamer 407 Vaginal controlled delivery system Curcumin Drug delivery Highlights Tsol–gel hydrogel was prepared with biocompatible materials for vaginal administration. The solid dispersion technique was used to improve the curcumin water http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Sol-Gel Science and Technology Springer Journals

Formulation and evaluation of thermoresponsive polymeric blend as a vaginal controlled delivery system

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Publisher
Springer US
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Materials Science; Ceramics, Glass, Composites, Natural Materials; Inorganic Chemistry; Optical and Electronic Materials; Nanotechnology
ISSN
0928-0707
eISSN
1573-4846
D.O.I.
10.1007/s10971-018-4662-6
Publisher site
See Article on Publisher Site

Abstract

In this research, a thermosensitive system with proper physiomechanical properties and prepared with biocompatible materials was used to increase mucoadhesion, to control drug delivery and to decrease the local irritation. Thus, Tsol–gel temperatures approximately between 26–27 and 37–38 °C were found. The solid dispersion increases the solubility and Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10971-018-4662-6) contains supplementary material, which is available to authorized users. * Marco Chaud Laboratory of Toxicological Research, University of Sorocaba, marco.chaud@prof.uniso.br Sorocaba, São Paulo 18023-000, Brazil Laboratory of Nanotechnology and Nanomedicine, University of Laboratory of Biomaterials and Nanotechnology, University of Tiradentes, Aracaju, Sergipe 49010-390, Brazil Sorocaba, Sorocaba, São Paulo 18023-000, Brazil Biotechnology Laboratory, S G B Amrãvati University, Laboratory of Biotechnology, University of Sorocaba, Amrãvati 444-602, India Sorocaba, São Paulo 18023-000, Brazil 1234567890();,: 1234567890();,: Journal of Sol-Gel Science and Technology (2018) 86:536–552 537 stability of curcumin. This formulation was designed for treatment of vaginal mucositis, HPV, bacterial infection and other vaginal diseases. ● ● ● ● Keywords Thermoresponsive hydrogel Polymeric blends Poloxamer 407 Vaginal controlled delivery system Curcumin Drug delivery Highlights Tsol–gel hydrogel was prepared with biocompatible materials for vaginal administration. The solid dispersion technique was used to improve the curcumin water

Journal

Journal of Sol-Gel Science and TechnologySpringer Journals

Published: May 4, 2018

References

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