J. Membrane Biol. 213, 65–66 (2006) DOI: 10.1007/s00232-006-0874-8 Thematic Issue Amino Acid Transporters: Structure and Mechanism R. Deves, C.A.R. Boyd, Guest Editors 1 2 R. Deve´ s , C.A.R. Boyd Dept. Fisiologia y Bioﬁsica, Universidad de Chile, Santiago 7, Chile, Dept. Physiology, Anatomy & Genetics, South Parks Road, Oxford, OX1 3QX Received: 10 November 2006 As with other areas of transport biology the study of (OMara, Oakley and Broeer, 2006) and the impact amino acid transport in eukaryotes was revolution- on these studies of structural work; a transporter ized by the arrival (Kim et al., 1991; Wang et al. 1991) modelling approach for studies on the SLC15 family of molecular sequences of proteins that catalyze PepT1 transporter (Meredith & Price, 2006) that uses membrane transport of such solutes. And more re- published structures of other bacterial transporters to cently the ﬁeld has been reinvigorated by the model a mammalian transporter for alpha-amino appearance in the literature of three-dimensional nitrogen, important both for nutrition and for drug structures, at the atomic level, for prokaryote mem- delivery; and a review of the cationic amino acid bers of a few of these transporters ( e.g., Yernool transporters, SLC7 family members, including very
The Journal of Membrane Biology – Springer Journals
Published: Apr 6, 2007
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