Fluorouracil/folinic-acid/oxaliplatin

Fluorouracil/folinic-acid/oxaliplatin Reactions 1680, p144 - 2 Dec 2017 Peripheral sensory neuropathy: case report In a retrospective study of 143 patients , a patient [age and sex not stated] was described who developed grade 3 peripheral sensory neuropathy after receiving oxaliplatin, folinic acid [leucovorin], fluorouracil [5-fluorouracil]. The patient, who had stage 3 colon cancer, received FOLFOX4 regimen which included oxaliplatin 85 mg/m as two hour infusion on day one, folinic acid [dose not clearly stated] as two hour infusion on day one and day two, and an IV bolus of fluorouracil 400 mg/m as loading dose, followed by fluorouracil 600 mg/m via ambulatory pump for 22 hours on day one and day two. All doses were given biweekly. The patient developed grade 3 peripheral sensory neuropathy [duration of treatment to reaction onset and outcome not stated]. Author comment: "15 FOLFOXU patients (18.5%) experienced peripheral sensory neuropathy (grade 3 in 1 FOLFOX4 patient and in 2 FOLFOXU patients)". Huang M-Y, et al. Comparison of adjuvant FOLFOX4 chemotherapy and oral UFUR/LV following adjuvant FOLFOX4 chemotherapy in patients with stage III colon cancer subsequent to radical resection. Oncology Letters 14: 6754-6762, No. 6, Dec 2017. Available from: URL: http://doi.org/10.3892/ol.2017.7073 - Taiwan 803284405 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Fluorouracil/folinic-acid/oxaliplatin

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
Free
1 page
Loading next page...
1 Page
 
/lp/springer_journal/fluorouracil-folinic-acid-oxaliplatin-uNpWlvhZff
Publisher
Springer International Publishing
Copyright
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-017-39075-4
Publisher site
See Article on Publisher Site

Abstract

Reactions 1680, p144 - 2 Dec 2017 Peripheral sensory neuropathy: case report In a retrospective study of 143 patients , a patient [age and sex not stated] was described who developed grade 3 peripheral sensory neuropathy after receiving oxaliplatin, folinic acid [leucovorin], fluorouracil [5-fluorouracil]. The patient, who had stage 3 colon cancer, received FOLFOX4 regimen which included oxaliplatin 85 mg/m as two hour infusion on day one, folinic acid [dose not clearly stated] as two hour infusion on day one and day two, and an IV bolus of fluorouracil 400 mg/m as loading dose, followed by fluorouracil 600 mg/m via ambulatory pump for 22 hours on day one and day two. All doses were given biweekly. The patient developed grade 3 peripheral sensory neuropathy [duration of treatment to reaction onset and outcome not stated]. Author comment: "15 FOLFOXU patients (18.5%) experienced peripheral sensory neuropathy (grade 3 in 1 FOLFOX4 patient and in 2 FOLFOXU patients)". Huang M-Y, et al. Comparison of adjuvant FOLFOX4 chemotherapy and oral UFUR/LV following adjuvant FOLFOX4 chemotherapy in patients with stage III colon cancer subsequent to radical resection. Oncology Letters 14: 6754-6762, No. 6, Dec 2017. Available from: URL: http://doi.org/10.3892/ol.2017.7073 - Taiwan 803284405 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680

Journal

Reactions WeeklySpringer Journals

Published: Dec 2, 2017

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off