Fluorouracil/folinic-acid/oxaliplatin Reactions 1680, p144 - 2 Dec 2017 Peripheral sensory neuropathy: case report In a retrospective study of 143 patients , a patient [age and sex not stated] was described who developed grade 3 peripheral sensory neuropathy after receiving oxaliplatin, folinic acid [leucovorin], fluorouracil [5-fluorouracil]. The patient, who had stage 3 colon cancer, received FOLFOX4 regimen which included oxaliplatin 85 mg/m as two hour infusion on day one, folinic acid [dose not clearly stated] as two hour infusion on day one and day two, and an IV bolus of fluorouracil 400 mg/m as loading dose, followed by fluorouracil 600 mg/m via ambulatory pump for 22 hours on day one and day two. All doses were given biweekly. The patient developed grade 3 peripheral sensory neuropathy [duration of treatment to reaction onset and outcome not stated]. Author comment: "15 FOLFOXU patients (18.5%) experienced peripheral sensory neuropathy (grade 3 in 1 FOLFOX4 patient and in 2 FOLFOXU patients)". Huang M-Y, et al. Comparison of adjuvant FOLFOX4 chemotherapy and oral UFUR/LV following adjuvant FOLFOX4 chemotherapy in patients with stage III colon cancer subsequent to radical resection. Oncology Letters 14: 6754-6762, No. 6, Dec 2017. Available from: URL: http://doi.org/10.3892/ol.2017.7073 - Taiwan 803284405 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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