Fluconazole

Fluconazole Reactions 1680, p141 - 2 Dec 2017 Hepatic transaminitis: case report A 33-year-old woman developed hepatic transaminitis following treatment with fluconazole. The woman received fluconazole 800mg [route not stated] for treatment of coccidioidomycosis endophthalmitis. Afterwards, she developed hepatic transaminitis [duration of treatment to reaction onset not stated]. Fluconazole was switched to posaconazole. Subsequently, his liver function normalised. Author comment: "In the context of our patient, we believe that it was reasonable to use posaconazole, given the expected chronic inflammation associated with coccidioidal endophthalmitis allowing for intraocular penetration and the hepatic transaminitis that developed on fluconazole (which is structurally similar to voriconazole)." Ling JJ, et al. Favorable Outcome in Coccidioides Endophthalmitis - A Combined Medical and Surgical Treatment Approach. Cornea 36: 1423-1425, No. 11, Nov 2017. Available from: URL: http://doi.org/10.1097/ICO.0000000000001353 - USA 803284136 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Fluconazole

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Publisher
Springer International Publishing
Copyright
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-017-39072-4
Publisher site
See Article on Publisher Site

Abstract

Reactions 1680, p141 - 2 Dec 2017 Hepatic transaminitis: case report A 33-year-old woman developed hepatic transaminitis following treatment with fluconazole. The woman received fluconazole 800mg [route not stated] for treatment of coccidioidomycosis endophthalmitis. Afterwards, she developed hepatic transaminitis [duration of treatment to reaction onset not stated]. Fluconazole was switched to posaconazole. Subsequently, his liver function normalised. Author comment: "In the context of our patient, we believe that it was reasonable to use posaconazole, given the expected chronic inflammation associated with coccidioidal endophthalmitis allowing for intraocular penetration and the hepatic transaminitis that developed on fluconazole (which is structurally similar to voriconazole)." Ling JJ, et al. Favorable Outcome in Coccidioides Endophthalmitis - A Combined Medical and Surgical Treatment Approach. Cornea 36: 1423-1425, No. 11, Nov 2017. Available from: URL: http://doi.org/10.1097/ICO.0000000000001353 - USA 803284136 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680

Journal

Reactions WeeklySpringer Journals

Published: Dec 2, 2017

References

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